Novel mastadenovirus infection and clinical disease in a pygmy marmoset (Callithrix [Cebuella] pygmaea)

We describe the detection and successful isolation of a novel mastadenovirus from a pygmy marmoset (Callithrix [Cebuella] pygmaea) that died following an episode of severe respiratory signs. Pathologic/histopathologic examination revealed hydrothorax and catarrhal bronchopneumonia with pronounced de...

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Vydáno v:	Veterinary microbiology Ročník 167; číslo 3-4; s. 695 - 699
Hlavní autoři:	Gál, János, Hornyák, Ákos, Mándoki, Míra, Bakonyi, Tamás, Balka, Gyula, Szeredi, Levente, Marosán, Miklós, Ludányi, Tibor, Forgách, Petra, Sós, Endre, Demeter, Zoltán, Farkas, Szilvia L.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Netherlands Elsevier B.V 27.12.2013
Témata:	Adenoviridae Adenoviridae Infections Adenoviridae Infections - pathology Adenoviridae Infections - veterinary Adenoviridae Infections - virology Animals Animals, Zoo Animals, Zoo - virology bronchopneumonia Callithrix Callithrix (Cebuella) pygmaea Callithrix - virology Canine adenovirus A Canine mastadenovirus A Cattle Cell Line Cercopithecus aethiops Chiroptera Chlorocebus aethiops classification DNA-Directed DNA Polymerase DNA-Directed DNA Polymerase - genetics dogs epithelial cells Equine adenovirus A Equine mastadenovirus A genes genetics giant cells Hungary hyperplasia isolation & purification Male Mastadenovirus Mastadenovirus - classification Mastadenovirus - genetics Mastadenovirus - isolation & purification Mastadenovirus - physiology Monkey Diseases Monkey Diseases - pathology Monkey Diseases - virology pathology Phylogeny physiology Pygmy marmoset Vero Cells veterinary virology virus transmission Hungary Mastadenovirus Callithrix (Cebuella) pygmaea Adenoviridae Pygmy marmoset
ISSN:	0378-1135, 1873-2542, 1873-2542
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Shrnutí:	We describe the detection and successful isolation of a novel mastadenovirus from a pygmy marmoset (Callithrix [Cebuella] pygmaea) that died following an episode of severe respiratory signs. Pathologic/histopathologic examination revealed hydrothorax and catarrhal bronchopneumonia with pronounced desquamation of the bronchiolar epithelial cells, while in other airways a marked hyperplasia of the epithelial lining and numerous giant cells could be observed. We obtained partial sequence data from the adenoviral DNA-dependent DNA-polymerase gene of the isolated strain and analyses of this region showed the highest level of identity to the recently described bat adenoviruses (strains PPV1 and TJM) and the type 2 canine adenovirus. Similar results were gained by phylogenetic calculations indicating that this novel marmoset adenovirus is only distantly related to reference Old and New World primate adenoviruses and formed a monophyletic group with bat and canine adenoviruses and the equine adenovirus 1. Even though the source of the infection remained unknown, our results could imply the possibility of a cross-species transmission of the virus from an anonymous host to the pygmy marmoset.
Bibliografie:	http://dx.doi.org/10.1016/j.vetmic.2013.08.008 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0378-1135 1873-2542 1873-2542
DOI:	10.1016/j.vetmic.2013.08.008