Novel mastadenovirus infection and clinical disease in a pygmy marmoset (Callithrix [Cebuella] pygmaea)

We describe the detection and successful isolation of a novel mastadenovirus from a pygmy marmoset (Callithrix [Cebuella] pygmaea) that died following an episode of severe respiratory signs. Pathologic/histopathologic examination revealed hydrothorax and catarrhal bronchopneumonia with pronounced de...

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Published in:Veterinary microbiology Vol. 167; no. 3-4; pp. 695 - 699
Main Authors: Gál, János, Hornyák, Ákos, Mándoki, Míra, Bakonyi, Tamás, Balka, Gyula, Szeredi, Levente, Marosán, Miklós, Ludányi, Tibor, Forgách, Petra, Sós, Endre, Demeter, Zoltán, Farkas, Szilvia L.
Format: Journal Article
Language:English
Published: Netherlands Elsevier B.V 27.12.2013
Subjects:
Adenoviridae
Adenoviridae Infections
Adenoviridae Infections - pathology
Adenoviridae Infections - veterinary
Adenoviridae Infections - virology
Animals
Animals, Zoo
Animals, Zoo - virology
bronchopneumonia
Callithrix
Callithrix (Cebuella) pygmaea
Callithrix - virology
Canine adenovirus A
Canine mastadenovirus A
Cattle
Cell Line
Cercopithecus aethiops
Chiroptera
Chlorocebus aethiops
classification
DNA-Directed DNA Polymerase
DNA-Directed DNA Polymerase - genetics
dogs
epithelial cells
Equine adenovirus A
Equine mastadenovirus A
genes
genetics
giant cells
Hungary
hyperplasia
isolation & purification
Male
Mastadenovirus
Mastadenovirus - classification
Mastadenovirus - genetics
Mastadenovirus - isolation & purification
Mastadenovirus - physiology
Monkey Diseases
Monkey Diseases - pathology
Monkey Diseases - virology
pathology
Phylogeny
physiology
Pygmy marmoset
Vero Cells
veterinary
virology
virus transmission
Hungary
Mastadenovirus
Callithrix (Cebuella) pygmaea
Adenoviridae
Pygmy marmoset
ISSN:0378-1135, 1873-2542, 1873-2542
Online Access:Get full text
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Summary:We describe the detection and successful isolation of a novel mastadenovirus from a pygmy marmoset (Callithrix [Cebuella] pygmaea) that died following an episode of severe respiratory signs. Pathologic/histopathologic examination revealed hydrothorax and catarrhal bronchopneumonia with pronounced desquamation of the bronchiolar epithelial cells, while in other airways a marked hyperplasia of the epithelial lining and numerous giant cells could be observed. We obtained partial sequence data from the adenoviral DNA-dependent DNA-polymerase gene of the isolated strain and analyses of this region showed the highest level of identity to the recently described bat adenoviruses (strains PPV1 and TJM) and the type 2 canine adenovirus. Similar results were gained by phylogenetic calculations indicating that this novel marmoset adenovirus is only distantly related to reference Old and New World primate adenoviruses and formed a monophyletic group with bat and canine adenoviruses and the equine adenovirus 1. Even though the source of the infection remained unknown, our results could imply the possibility of a cross-species transmission of the virus from an anonymous host to the pygmy marmoset.
Bibliography:http://dx.doi.org/10.1016/j.vetmic.2013.08.008
ObjectType-Article-1
SourceType-Scholarly Journals-1
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content type line 23
ISSN:0378-1135
1873-2542
1873-2542
DOI:10.1016/j.vetmic.2013.08.008