Influenza vaccination and major cardiovascular risk: a systematic review and meta-analysis of clinical trials studies

Cardiovascular events remain a substantial global health concern, necessitating innovative strategies for prevention. This study aims to assess the potential impact of influenza vaccination on major cardiovascular events. A search of the medical English literature was conducted using PubMed/MEDLINE,...

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Vydáno v:Scientific reports Ročník 13; číslo 1; s. 20235 - 7
Hlavní autoři: Omidi, Fatemeh, Zangiabadian, Moein, Shahidi Bonjar, Amir Hashem, Nasiri, Mohammad Javad, Sarmastzadeh, Tala
Médium: Journal Article
Jazyk:angličtina
Vydáno: London Nature Publishing Group UK 19.11.2023
Nature Publishing Group
Nature Portfolio
Témata:
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692/4019
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Cardiovascular diseases
Cardiovascular Diseases - prevention & control
Cerebral infarction
Clinical trials
Death
Global health
Health risks
Heart attacks
Heart Disease Risk Factors
Humanities and Social Sciences
Humans
Immunization
Influenza
Influenza Vaccines
Influenza, Human - prevention & control
Meta-analysis
Mortality
multidisciplinary
Myocardial infarction
Myocardial Infarction - epidemiology
Myocardial Infarction - prevention & control
Patients
Placebos
Prevention
Public health
Risk assessment
Risk Factors
Science
Science (multidisciplinary)
Vaccination
Vaccines
ISSN:2045-2322, 2045-2322
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Shrnutí:Cardiovascular events remain a substantial global health concern, necessitating innovative strategies for prevention. This study aims to assess the potential impact of influenza vaccination on major cardiovascular events. A search of the medical English literature was conducted using PubMed/MEDLINE, EMBASE, and the Cochrane CENTRAL up to 1 August 2023. Meta-analysis and stratified analyses were performed to investigate specific outcomes, including myocardial infarction (MI), cardiovascular death, and stroke. Pooled relative risks (RR) along with their 95% confidence intervals (CI) were calculated to evaluate the associations. A comprehensive analysis was conducted on a total of 9059 patients, with 4529 patients receiving the influenza vaccine and 4530 patients receiving a placebo. Among patients who received the influenza vaccine, a notable reduction in the occurrence of major cardiovascular events was observed, with 517 cases compared to 621 cases in the placebo group (RR 0.70; 95% CI 0.55–0.91). The stratified analysis revealed a decreased risk of MI in vaccinated patients (RR 0.74; 95% CI 0.56–0.97) and a significant reduction in cardiovascular death events (RR 0.67; 95% CI 0.45–0.98). This study provides compelling evidence that influenza vaccination is associated with a decreased risk of major cardiovascular events, particularly myocardial infarction, and cardiovascular death. These findings highlight the potential of influenza vaccination as an adjunctive strategy in cardiovascular disease prevention. Further research and exploration of underlying mechanisms are warranted to elucidate the observed beneficial effects.
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ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-023-47690-9