Wireless, battery-free, multifunctional integrated bioelectronics for respiratory pathogens monitoring and severity evaluation

The rapid diagnosis of respiratory virus infection through breath and blow remains challenging. Here we develop a wireless, battery-free, multifunctional pathogenic infection diagnosis system (PIDS) for diagnosing SARS-CoV-2 infection and symptom severity by blow and breath within 110 s and 350 s, r...

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Veröffentlicht in:Nature communications Jg. 14; H. 1; S. 7539 - 13
Hauptverfasser: Li, Hu, Gong, Huarui, Wong, Tsz Hung, Zhou, Jingkun, Wang, Yuqiong, Lin, Long, Dou, Ying, Jia, Huiling, Huang, Xingcan, Gao, Zhan, Shi, Rui, Huang, Ya, Chen, Zhenlin, PARK, Wooyoung, Li, Ji Yu, Chu, Hongwei, Jia, Shengxin, Wu, Han, Wu, Mengge, Liu, Yiming, Li, Dengfeng, Li, Jian, Xu, Guoqiang, Chang, Tianrui, Zhang, Binbin, Gao, Yuyu, Su, Jingyou, Bai, Hao, Hu, Jie, Yiu, Chun Ki, Xu, Chenjie, Hu, Wenchuang, Huang, Jiandong, Chang, Lingqian, Yu, Xinge
Format: Journal Article
Sprache:Englisch
Veröffentlicht: London Nature Publishing Group UK 20.11.2023
Nature Publishing Group
Nature Portfolio
Schlagworte:
631/154/140
639/166/985
692/53/2421
692/699/255/2514
9/10
Biomarkers
Body Fluids
COVID-19 - diagnosis
Diagnosis
Humanities and Social Sciences
Humans
Infections
Machine learning
multidisciplinary
Pandemics
Respiratory diseases
Saliva
SARS-CoV-2
Science
Science (multidisciplinary)
Secretions
Severe acute respiratory syndrome coronavirus 2
Specimen Handling
Viral diseases
Viral infections
Wearable technology
ISSN:2041-1723, 2041-1723
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Zusammenfassung:The rapid diagnosis of respiratory virus infection through breath and blow remains challenging. Here we develop a wireless, battery-free, multifunctional pathogenic infection diagnosis system (PIDS) for diagnosing SARS-CoV-2 infection and symptom severity by blow and breath within 110 s and 350 s, respectively. The accuracies reach to 100% and 92% for evaluating the infection and symptom severity of 42 participants, respectively. PIDS realizes simultaneous gaseous sample collection, biomarker identification, abnormal physical signs recording and machine learning analysis. We transform PIDS into other miniaturized wearable or portable electronic platforms that may widen the diagnostic modes at home, outdoors and public places. Collectively, we demonstrate a general-purpose technology for rapidly diagnosing respiratory pathogenic infection by breath and blow, alleviating the technical bottleneck of saliva and nasopharyngeal secretions. PIDS may serve as a complementary diagnostic tool for other point-of-care techniques and guide the symptomatic treatment of viral infections. The SARS-CoV-2 pandemic highlighted our need for methods that allow rapid viral surveillance. Here, authors report a wireless, battery-free and wearable self-diagnosis platform that can continuously capture viral particles, diagnose infection status and evaluate symptom severity via breath and blow.
Bibliographie:ObjectType-Article-1
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ISSN:2041-1723
2041-1723
DOI:10.1038/s41467-023-43189-z