Recognition and inhibition of SARS-CoV-2 by humoral innate immunity pattern recognition molecules

The humoral arm of innate immunity includes diverse molecules with antibody-like functions, some of which serve as disease severity biomarkers in coronavirus disease 2019 (COVID-19). The present study was designed to conduct a systematic investigation of the interaction of human humoral fluid-phase...

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Bibliographic Details
Published in:	Nature immunology Vol. 23; no. 2; pp. 275 - 286
Main Authors:	Stravalaci, Matteo, Pagani, Isabel, Paraboschi, Elvezia Maria, Pedotti, Mattia, Doni, Andrea, Scavello, Francesco, Mapelli, Sarah N, Sironi, Marina, Perucchini, Chiara, Varani, Luca, Matkovic, Milos, Cavalli, Andrea, Cesana, Daniela, Gallina, Pierangela, Pedemonte, Nicoletta, Capurro, Valeria, Clementi, Nicola, Mancini, Nicasio, Invernizzi, Pietro, Bayarri-Olmos, Rafael, Garred, Peter, Rappuoli, Rino, Duga, Stefano, Bottazzi, Barbara, Uguccioni, Mariagrazia, Asselta, Rosanna, Vicenzi, Elisa, Mantovani, Alberto, Garlanda, Cecilia
Format:	Journal Article
Language:	English
Published:	United States Nature Publishing Group 01.02.2022
Subjects:	Animals Antiviral activity Antiviral drugs C-Reactive Protein - immunology C-Reactive Protein - metabolism Case-Control Studies Chlorocebus aethiops Complement Activation Coronavirus Nucleocapsid Proteins - genetics Coronavirus Nucleocapsid Proteins - immunology Coronavirus Nucleocapsid Proteins - metabolism Coronaviruses COVID-19 COVID-19 - immunology COVID-19 - metabolism COVID-19 - virology Female Gene polymorphism Glycosylation HEK293 Cells Host-Pathogen Interactions Humans Humoral immunity Immunity, Humoral Innate immunity Lectins Male Mannose Mannose-binding lectin Mannose-Binding Lectin - genetics Mannose-Binding Lectin - immunology Mannose-Binding Lectin - metabolism Nucleocapsids Pattern recognition Pattern recognition receptors Pentraxins Phosphoproteins - genetics Phosphoproteins - immunology Phosphoproteins - metabolism Polymorphism, Genetic Protein Binding Proteins Receptors, Pattern Recognition - genetics Receptors, Pattern Recognition - immunology Receptors, Pattern Recognition - metabolism Respiration SARS-CoV-2 - genetics SARS-CoV-2 - immunology SARS-CoV-2 - metabolism SARS-CoV-2 - pathogenicity Serum Amyloid P-Component - immunology Serum Amyloid P-Component - metabolism Severe acute respiratory syndrome coronavirus 2 Signal Transduction Spike Glycoprotein, Coronavirus - genetics Spike Glycoprotein, Coronavirus - immunology Spike Glycoprotein, Coronavirus - metabolism Spike protein Vero Cells
ISSN:	1529-2908, 1529-2916, 1529-2916
Online Access:	Get full text
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