Self-reported parkinsonian symptoms in the EPIC-Norfolk cohort

Parkinsonian symptoms have been associated with increased morbidity and mortality. Several studies have reported on the prevalence of signs and symptoms. Symptoms questionnaires can identify potential PD cases for further neurological examination to save resources. They can also provide information...

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Veröffentlicht in:BMC neurology Jg. 5; H. 1; S. 15
Hauptverfasser: Ishihara, Lianna S, Khaw, Kay-Tee, Luben, Robert, Bingham, Sheila, Welch, Ailsa, Day, Nicholas, Brayne, Carol
Format: Journal Article
Sprache:Englisch
Veröffentlicht: England BioMed Central 24.08.2005
BMC
Schlagworte:
Aged
Cohort Studies
Cross-Sectional Studies
Data Collection
Diagnosis, Differential
Epidemiologic Methods
Female
Humans
Male
Middle Aged
Parkinson Disease - epidemiology
Parkinson Disease - physiopathology
Population Groups
Prevalence
Self-Assessment
Severity of Illness Index
Surveys and Questionnaires
United Kingdom
ISSN:1471-2377, 1471-2377
Online-Zugang:Volltext
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Zusammenfassung:Parkinsonian symptoms have been associated with increased morbidity and mortality. Several studies have reported on the prevalence of signs and symptoms. Symptoms questionnaires can identify potential PD cases for further neurological examination to save resources. They can also provide information about how much of the population reports specific signs and symptoms. The objective of the study was to determine the self-reported prevalence of parkinsonian symptoms from a questionnaire, and to examine their association with age and self-reported Parkinson's disease in a large cohort. A cross-sectional study was conducted within a sub-cohort of the EPIC-Norfolk (European Prospective Investigation of Cancer) cohort study. The prevalence of six self-reported parkinsonian symptoms are reported for 11,539 individuals who answered all symptoms questions (62% of sub-cohort): rest tremor (4%), difficulty starting to walk (4%), difficulty getting out of a chair (6%), slower walking (34%), smaller handwriting (micrographia- 9%), and less acute sense of smell (olfactory dysfunction- 9%). The presence of individual symptoms increased with age except for difficulty getting out of a chair. The results support previous findings that the presence of self-reported parkinsonian symptoms is strongly associated with age and self-reported PD diagnosis. The data also provide information regarding the prevalence of symptoms in a large, younger population of adults than previously reported in the literature.
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ISSN:1471-2377
1471-2377
DOI:10.1186/1471-2377-5-15