174G>C interleukin-6 gene polymorphism in Tunisian patients with coronary artery disease

A state of low-grade inflammation accompanies the pathogenesis of atherosclerotic events. Interleukin-6 (IL-6) is a pleotropic pro-inflammatory cytokine that modulates the development of acute coronary syndromes (ACSs), partly by destabilizing coronary atherosclerotic plaques. We have examined the c...

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Bibliographic Details
Published in:Annals of Saudi medicine Vol. 31; no. 1; pp. 40 - 44
Main Authors: Ghazouani, Lakhdar, Abboud, Nesrine, Khalifa, Sonia Ben Hadj, Added, Faouzi, Khalfallah, Ali Ben, Nsiri, Brahim, Mediouni, Mounira, Mahjoub, Touhami
Format: Journal Article
Language:English
Published: Saudi Arabia KING FAISAL SPECIALIST HOSPITAL & RESEARCH CENTRE 01.01.2011
Medknow Publications
King Faisal Specialist Hospital and Research Centre
Subjects:
Aged
Alleles
Cardiovascular disease
Case-Control Studies
Coronary Artery Disease - genetics
Coronary vessels
Cytokines
Female
Genes
Genotype
Humans
Interleukin-6 - genetics
Logistic Models
Male
Middle Aged
Mutation
Original
Polymorphism, Single Nucleotide
Promoter Regions, Genetic
Risk Factors
Tunisia
Tunisia
ISSN:0256-4947, 0975-4466, 0975-4466
Online Access:Get full text
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Summary:A state of low-grade inflammation accompanies the pathogenesis of atherosclerotic events. Interleukin-6 (IL-6) is a pleotropic pro-inflammatory cytokine that modulates the development of acute coronary syndromes (ACSs), partly by destabilizing coronary atherosclerotic plaques. We have examined the contribution of the -174G>C IL-6 promoter variant on the risk of coronary artery disease (CAD) among Tunisians. Study subjects included 418 CAD patients and 406 age- and sex-matched controls. IL-6 genotyping was done by PCR-restriction fragment length polymorphism. The frequency of the -174C allele (mutant) was lower in Tunisians than in Europeans, and the distribution of -174 G>C genotypes was similar between CAD patients and control subjects. Moreover, compared to GG genotype carriers, -174C allele carriage did not increase the CAD relative risk (odds ratio and 95% confidence interval=1.09 and 0.80-1.49), which remained nonsignificant after adjusting for traditional risk factors for CAD (age, smoking, hypertension, diabetes and obesity). The -174G>C IL-6 promoter variant is not associated with an increased risk of CAD among Tunisians.
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ISSN:0256-4947
0975-4466
0975-4466
DOI:10.4103/0256-4947.75777