Genomic RNA editing and its impact on Ebola virus adaptation during serial passages in cell culture and infection of guinea pigs

Synthesis of the structural, surface glycoprotein (GP) of Ebola virus (EBOV) is dependent on transcriptional RNA editing phenomenon. Editing results in the insertion of an extra adenosine by viral polymerase at the editing site (7 consecutive template uridines) during transcription of GP gene of the...

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Bibliographic Details
Published in:	The Journal of infectious diseases Vol. 204 Suppl 3; p. S941
Main Authors:	Volchkova, Valentina A, Dolnik, Olga, Martinez, Miguel J, Reynard, Olivier, Volchkov, Viktor E
Format:	Journal Article
Language:	English
Published:	United States 01.11.2011
Subjects:	Adaptation, Physiological Animals Cercopithecus aethiops Ebolavirus - genetics Ebolavirus - physiology Female Gene Expression Regulation, Viral - physiology Genome, Viral - genetics Guinea Pigs Hemorrhagic Fever, Ebola - virology RNA Editing - physiology RNA, Viral - genetics Serial Passage Vero Cells Viral Proteins - genetics Viral Proteins - metabolism Virus Replication - physiology
ISSN:	1537-6613, 1537-6613
Online Access:	Get more information
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