IL-1 and IL-1ra are key regulators of the inflammatory response to RNA vaccines

The use of lipid-formulated RNA vaccines for cancer or COVID-19 is associated with dose-limiting systemic inflammatory responses in humans that were not predicted from preclinical studies. Here, we show that the 'interleukin 1 (IL-1)-interleukin 1 receptor antagonist (IL-1ra)' axis regulat...

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Veröffentlicht in:	Nature immunology Jg. 23; H. 4; S. 532 - 542
Hauptverfasser:	Tahtinen, Siri, Tong, Ann-Jay, Himmels, Patricia, Oh, Jaehak, Paler-Martinez, Andres, Kim, Leesun, Wichner, Sara, Oei, Yoko, McCarron, Mark J, Freund, Emily C, Amir, Zhainib Adel, de la Cruz, Cecile C, Haley, Benjamin, Blanchette, Craig, Schartner, Jill M, Ye, Weilan, Yadav, Mahesh, Sahin, Ugur, Delamarre, Lélia, Mellman, Ira
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Nature Publishing Group 01.04.2022
Schlagworte:	Animals Cancer vaccines COVID-19 Cytokines IL-1β Inflammation Inflammation - immunology Inflammation - metabolism Interleukin 1 Interleukin 1 receptor antagonist Interleukin 1 Receptor Antagonist Protein - genetics Interleukin 1 Receptor Antagonist Protein - immunology Interleukin 1 receptors Interleukin 6 Interleukin-1 - genetics Interleukin-1 - immunology Leukocytes Lipids Mice mRNA vaccines mRNA Vaccines - adverse effects mRNA Vaccines - metabolism Ribonucleic acid RNA Signal transduction Toll-like receptors Vaccines Vaccines, Synthetic
ISSN:	1529-2908, 1529-2916, 1529-2916
Online-Zugang:	Volltext
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