Therapeutically harnessing extracellular vesicles

The field of extracellular vesicle (EV) research has developed rapidly over the last decade from the study of fundamental biology to a subject of significant clinical relevance. The potential of harnessing EVs in the diagnosis and treatment of diseases — including cancer and neurological and cardiov...

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Vydáno v:Nature reviews. Drug discovery Ročník 21; číslo 5; s. 379 - 399
Hlavní autoři: Cheng, Lesley, Hill, Andrew F.
Médium: Journal Article
Jazyk:angličtina
Vydáno: London Nature Publishing Group UK 01.05.2022
Nature Publishing Group
Témata:
631/80/304
692/308/2778
692/53/2421
Biomarkers
Biomedical and Life Sciences
Biomedicine
Biosynthesis
Biotechnology
Cancer
Cancer Research
Cardiovascular Diseases
Disease
Extracellular Vesicles
Humans
Medicinal Chemistry
Molecular Medicine
Neoplasms - drug therapy
Pathology
Pharmacology/Toxicology
Physiology
Plasma
Proteins
Review Article
ISSN:1474-1776, 1474-1784, 1474-1784
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Popis
Shrnutí:The field of extracellular vesicle (EV) research has developed rapidly over the last decade from the study of fundamental biology to a subject of significant clinical relevance. The potential of harnessing EVs in the diagnosis and treatment of diseases — including cancer and neurological and cardiovascular disorders — is now being recognized. Accordingly, the applications of EVs as therapeutic targets, biomarkers, novel drug delivery agents and standalone therapeutics are being actively explored. This Review provides a brief overview of the characteristics and physiological functions of the various classes of EV, focusing on their association with disease and emerging strategies for their therapeutic exploitation. The past decade has witnessed rapid growth in the field of extracellular vesicle (EV) research, and the potential of harnessing EVs in the treatment and diagnosis of diseases is now well recognized. Here, Cheng and Hill provide an overview of the physiological and pathological roles of EVs, discuss how they could be therapeutically exploited and consider the associated challenges.
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ISSN:1474-1776
1474-1784
1474-1784
DOI:10.1038/s41573-022-00410-w