Aging of Oocyte, Ovary, and Human Reproduction

: We review age‐related changes in the ovary and their effect on female fertility, with particular emphasis on follicle formation, follicle dynamics, and oocyte quality. The evidence indicates that the developmental processes leading to follicle formation set the rules determining follicle quiescenc...

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Vydáno v:Annals of the New York Academy of Sciences Ročník 1034; číslo 1; s. 117 - 131
Hlavní autoři: OTTOLENGHI, CHRIS, UDA, MANUELA, HAMATANI, TOSHIO, CRISPONI, LAURA, GARCIA, JOSE-ELIAS, KO, MINORU, PILIA, GIUSEPPE, SFORZA, CHIARELLA, SCHLESSINGER, DAVID, FORABOSCO, ANTONINO
Médium: Journal Article
Jazyk:angličtina
Vydáno: Oxford, UK Blackwell Publishing Ltd 01.12.2004
Témata:
Aging - physiology
Animals
developmental competence
Female
follicle dynamics
follicle endowment
histogenesis
Humans
meiotic competence
oocyte quality
Oocytes - cytology
Oocytes - physiology
Ovary - cytology
Ovary - physiology
POF
premature ovarian failure
Reproduction - physiology
ISSN:0077-8923, 1749-6632
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Popis
Shrnutí:: We review age‐related changes in the ovary and their effect on female fertility, with particular emphasis on follicle formation, follicle dynamics, and oocyte quality. The evidence indicates that the developmental processes leading to follicle formation set the rules determining follicle quiescence and growth. This regulatory system is maintained until menopause and is directly affected in at least some models of premature ovarian failure (POF), most strikingly in the Foxl2 mouse knockout, a model of human POF with monogenic etiology (blepharophimosis/ptosis/epicanthus inversus syndrome). Several lines of evidence indicate that if the ovarian germ cell lineage maintains regenerative potential, as recently suggested in the mouse, a role in follicle dynamics for germ stem cells, if any, is likely indirect or secondary. In addition, age‐related variations in oocyte quality in animal models suggest that reproductive competence is acquired progressively and might depend on parallel growth and differentiation of follicle cells and stroma. Genomewide analyses of the mouse oocyte transcriptome have begun to be used to systematically investigate the mechanisms of reproductive competence that are altered with aging. Investigative and therapeutic strategies can benefit from considering the role of continuous interactions between follicle cells and oocytes from the beginning of histogenesis to full maturation.
Bibliografie:istex:E285C4CC03634D84AD0F579A0336BC4A640D7839
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ArticleID:NYAS117
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ISSN:0077-8923
1749-6632
DOI:10.1196/annals.1335.015