The Incidence and Epidemiology of Hepatocellular Carcinoma: A Global and Regional Perspective

Hepatocellular carcinoma (HCC) is a leading cause of cancer‐related death worldwide, and the burden of this devastating cancer is expected to increase further in coming years. The collection and analysis of epidemiologic HCC data will play a critical role in guiding future disease prevention strateg...

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Veröffentlicht in:The oncologist (Dayton, Ohio) Jg. 15; H. S4; S. 5 - 13
Hauptverfasser: Venook, Alan P., Papandreou, Christos, Furuse, Junji, Ladrón de Guevara, Laura
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Durham, NC, USA AlphaMed Press 01.11.2010
Schlagworte:
Africa South of the Sahara - epidemiology
Carcinoma, Hepatocellular - epidemiology
Carcinoma, Hepatocellular - etiology
Carcinoma, Hepatocellular - virology
Epidemiology
Europe - epidemiology
Far East - epidemiology
Female
Hepatitis B - complications
Hepatitis B - epidemiology
Hepatitis B virus
Hepatitis C - complications
Hepatitis C - epidemiology
Hepatitis C virus
Hepatocellular carcinoma
Humans
Incidence
Liver Neoplasms - epidemiology
Liver Neoplasms - etiology
Liver Neoplasms - virology
Male
North America - epidemiology
Risk Factors
Africa South of the Sahara
Far East
North America
Europe
ISSN:1083-7159, 1549-490X, 1549-490X
Online-Zugang:Volltext
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Zusammenfassung:Hepatocellular carcinoma (HCC) is a leading cause of cancer‐related death worldwide, and the burden of this devastating cancer is expected to increase further in coming years. The collection and analysis of epidemiologic HCC data will play a critical role in guiding future disease prevention strategies and optimizing patient management. Previous epidemiologic studies have highlighted striking global variations in the incidence of HCC, which is particularly high in much of east Asia and sub‐Saharan Africa, and lower, but on the increase, in North America and most of Europe. This variation appears to be related to the complex etiology of HCC, with different risk factors, primarily infection with hepatitis B or hepatitis C virus, responsible for driving HCC incidence rates in different regions. Although previous studies have contributed considerably to the knowledge of HCC epidemiology, there are limitations associated with the currently available data, which arise from studies performed at different times in the past, using varying methodologies, and with diverse patient populations. A new and global approach to the study of HCC epidemiology is required if HCC disease prevention and treatment strategies are to be adequately directed and supported in coming years. This article reviews key aspects of hepatocellular carcinoma and epidemiology, highlights the limitations of current data, and identifies the need for new approaches in future research.
Bibliographie:Research funding/contracted research
Junji Furuse
Bayer/Onyx, Genentech, Roche, Novartis
Bayer.
Consultant/advisory role
Disclosures: Alan P. Venook
JCOG
Christos Papandreou
Bayer, Eli Lilly, Taiho
None
Laura Ladrón de Guevara
Honoraria
The content of this article has been reviewed by independent peer reviewers to ensure that it is balanced, objective, and free from commercial bias. No financial relationships relevant to the content of this article have been disclosed by the independent peer reviewers.
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ISSN:1083-7159
1549-490X
1549-490X
DOI:10.1634/theoncologist.2010-S4-05