Treating disorders of the neonatal central nervous system: pharmacokinetic and pharmacodynamic considerations with a focus on antiepileptics

A major consideration in the treatment of neonatal disorders is that the selected drug, dose and dosage frequency is safe, effective and appropriate for the intended patient population. Thus, a thorough knowledge of the pharmacokinetics and pharmacodynamics of the chosen drug within the patient popu...

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Bibliographic Details
Published in:	British journal of clinical pharmacology Vol. 81; no. 1; pp. 62 - 77
Main Authors:	Donovan, Maria D., Boylan, Geraldine B., Murray, Deirdre M., Cryan, John F., Griffin, Brendan T.
Format:	Journal Article
Language:	English
Published:	England John Wiley and Sons Inc 01.01.2016
Subjects:	Anticonvulsants - pharmacokinetics Anticonvulsants - pharmacology antiepileptics Blood-Brain Barrier Brain - metabolism Central Nervous System Diseases - drug therapy Humans Infant, Newborn Infant, Newborn, Diseases - drug therapy Models, Biological neonate patient‐specific computational modeling pharmacodynamics pharmacokinetics Review Reviews pharmacokinetics neonate antiepileptics patient-specific computational modeling pharmacodynamics
ISSN:	0306-5251, 1365-2125, 1365-2125
Online Access:	Get full text
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