Evaluation of the physical properties and stability of two lipid drug delivery systems containing mefloquine

Stability data is used to determine the change the product has undergone over a certain time period at specific temperatures. In the present study, the physical stability characterized by size, pH and entrapment efficacy of mefloquine loaded liposomes and Pheroid™ vesicles were investigated. Size wa...

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Vydáno v:	International journal of pharmaceutics Ročník 409; číslo 1; s. 209 - 215
Hlavní autoři:	Slabbert, C., Plessis, L.H. du, Kotzé, A.F.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Amsterdam Elsevier B.V 16.05.2011 Elsevier
Témata:	Antimalarials - administration & dosage Antimalarials - chemistry Bioavailability Biological and medical sciences Colloids Data processing Drug delivery Drug delivery system Drug Delivery Systems Drug Stability Drug Storage drugs Fatty Acids - chemistry Flow Cytometry General pharmacology Hydrogen-Ion Concentration Lipid bilayers Liposome Liposomes Medical sciences Mefloquine Mefloquine - administration & dosage Mefloquine - chemistry Mefloquine hydrochloride Particle Size pH effects Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Pheroid™ Technology Spectrophotometry, Ultraviolet Stability Characterization Storage conditions Temperature Temperature effects Toxicity Vesicles EE PBS MQ Liposome ICH Stability Characterization Mefloquine hydrochloride Pheroid™ Technology RH FSC CLSM Drug delivery system WHO Antimalarial Evaluation Mefloquine Stability Pharmaceutical technology Lipids Drug carrier Physical properties Characterization Parasiticide Physicochemical properties
ISSN:	0378-5173, 1873-3476, 1873-3476
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Shrnutí:	Stability data is used to determine the change the product has undergone over a certain time period at specific temperatures. In the present study, the physical stability characterized by size, pH and entrapment efficacy of mefloquine loaded liposomes and Pheroid™ vesicles were investigated. Size was accurately determined by flow cytometry. Entrapment efficacy, after unentrapped drug was removed was successfully determined by UV-spectrophotometry. The formulations contained 0.5% (m/v) mefloquine and results showed that mefloquine interfered with the formation of lipid bilayer of the liposomes. Liposomes increased in size from 5.22 ± 0.03 μm to 9.71 ± 1.11 μm with accelerated stability and large aggregates were observed. A notable difference in stability testing of Pheroid™ vesicles was seen with no significant increase in size. Entrapment efficacy of 68.72 ± 0.04% (5 °C), 67.45 ± 2.92% (25 °C) and 67.45 ± 2.92% (30 °C) were obtained at the different storage conditions. With these findings the mefloquine loaded Pheroid™ vesicles are stable and should be used investigated for the possible increase in efficacy and bioavailability and decrease toxicity.
Bibliografie:	http://dx.doi.org/10.1016/j.ijpharm.2011.01.050 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	0378-5173 1873-3476 1873-3476
DOI:	10.1016/j.ijpharm.2011.01.050