The micronucleus assay in human buccal cells as a tool for biomonitoring DNA damage: The HUMN project perspective on current status and knowledge gaps

The micronucleus (MN) assay in exfoliated buccal cells is a useful and minimally invasive method for monitoring genetic damage in humans. This overview has concluded that although MN assay in buccal cells has been used since the 1980s to demonstrate cytogenetic effects of environmental and occupatio...

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Bibliographic Details
Published in:	Mutation research Vol. 659; no. 1; pp. 93 - 108
Main Authors:	Holland, Nina, Bolognesi, Claudia, Kirsch-Volders, Micheline, Bonassi, Stefano, Zeiger, Errol, Knasmueller, Siegfried, Fenech, Michael
Format:	Journal Article
Language:	English
Published:	Lausanne Elsevier B.V 01.07.2008 Amsterdam Elsevier Science New York, NY
Subjects:	Biological and medical sciences Biomarkers Biomonitoring Cancer DNA Damage Environmental exposure Environmental Pollutants - toxicity Evaluation Studies as Topic Exfoliated cell Forecasting Fundamental and applied biological sciences. Psychology Genotoxicity Humans Medical sciences Metabolic diseases Micronucleus Tests - methods Micronucleus Tests - standards Micronucleus Tests - trends Molecular and cellular biology Molecular genetics Mouth Mucosa - cytology Mutagenesis. Repair Occupational exposure Oral epithelia Other nutritional diseases (malnutrition, nutritional and vitamin deficiencies...) Precancerous lesion Scoring criteria Smoking Tobacco, tobacco smoking Toxicology Validation Studies as Topic Vitamin deficiency Environmental exposure Biomonitoring Exfoliated cell Genotoxicity Biomarkers Vitamin deficiency Occupational exposure Precancerous lesion Scoring criteria Cancer Oral epithelia Smoking Toxicity Tobacco smoking Biological marker Perspective Micronucleus Malnutrition Nutritional status GTPase activating protein Human Premalignant lesion Mutagenicity testing Nutrition disorder Malignant tumor Oral cavity Metabolic disorder DNA Environment
ISSN:	1383-5742, 0027-5107, 1388-2139
Online Access:	Get full text
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