Antiviral activity of berberine

Plants are a rich source of new antiviral, pharmacologically active agents. The naturally occurring plant alkaloid berberine (BBR) is one of the phytochemicals with a broad range of biological activity, including anticancer, anti-inflammatory and antiviral activity. BBR targets different steps in th...

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Bibliographic Details
Published in:Archives of virology Vol. 165; no. 9; pp. 1935 - 1945
Main Authors: Warowicka, Alicja, Nawrot, Robert, Goździcka-Józefiak, Anna
Format: Journal Article
Language:English
Published: Vienna Springer Vienna 01.09.2020
Springer Nature B.V
Subjects:
Antiviral activity
Antiviral agents
Antiviral drugs
antiviral properties
Berberine
Biological activity
Biomedical and Life Sciences
Biomedicine
COVID-19
COVID-19 infection
Deoxyribonucleic acid
DNA
DNA biosynthesis
DNA replication
Drug development
Herpes simplex
HIV
Human betaherpesvirus 5
Human immunodeficiency virus
Human papillomavirus
humans
Immune clearance
Immune response
Immunosuppressive agents
Infectious Diseases
Inflammation
Intercalating agents
Life cycles
Medical Microbiology
medicinal properties
NF-κB protein
pandemic
Pandemics
Papillomaviridae
phytochemicals
Replication
Review
RNA-directed DNA polymerase
Severe acute respiratory syndrome coronavirus 2
TOR protein
Virology
virus replication
viruses
ISSN:0304-8608, 1432-8798, 1432-8798
Online Access:Get full text
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Summary:Plants are a rich source of new antiviral, pharmacologically active agents. The naturally occurring plant alkaloid berberine (BBR) is one of the phytochemicals with a broad range of biological activity, including anticancer, anti-inflammatory and antiviral activity. BBR targets different steps in the viral life cycle and is thus a good candidate for use in novel antiviral drugs and therapies. It has been shown that BBR reduces virus replication and targets specific interactions between the virus and its host. BBR intercalates into DNA and inhibits DNA synthesis and reverse transcriptase activity. It inhibits replication of herpes simplex virus (HSV), human cytomegalovirus (HCMV), human papillomavirus (HPV), and human immunodeficiency virus (HIV). This isoquinoline alkaloid has the ability to regulate the MEK-ERK, AMPK/mTOR, and NF-κB signaling pathways, which are necessary for viral replication. Furthermore, it has been reported that BBR supports the host immune response, thus leading to viral clearance. In this short review, we focus on the most recent studies on the antiviral properties of berberine and its derivatives, which might be promising agents to be considered in future studies in the fight against the current pandemic SARS-CoV-2, the virus that causes COVID-19.
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Handling Editor: Carolina Scagnolari.
ISSN:0304-8608
1432-8798
1432-8798
DOI:10.1007/s00705-020-04706-3