Effects of Lactoferrin on Prevention of Acute Gastrointestinal Symptoms in Winter: A Randomized, Double-Blinded, Placebo-Controlled Trial for Staff of Kindergartens and Nursery Schools in Japan

This study investigated the preventive effects of lactoferrin (LF) on subjective acute gastrointestinal symptoms during the winter in a randomized, double-blinded, placebo-controlled parallel-group comparative trial. The eligible subjects were healthy adults working at kindergartens and nursery scho...

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Veröffentlicht in:International journal of environmental research and public health Jg. 17; H. 24; S. 9582
Hauptverfasser: Mizuki, Masaru, Tsukahara, Teruomi, Oda, Hirotsugu, Tanaka, Miyuki, Yamauchi, Koji, Abe, Fumiaki, Nomiyama, Tetsuo
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Switzerland MDPI AG 21.12.2020
MDPI
Schlagworte:
Adult
Anti-Infective Agents - therapeutic use
Day care centers
Double-Blind Method
Female
Food products
Gastroenteritis
Gastrointestinal Diseases - drug therapy
Gastrointestinal Diseases - epidemiology
Gastrointestinal Diseases - prevention & control
Health care
Humans
Infectious diseases
Informed consent
Japan - epidemiology
Lactoferrin - therapeutic use
Milk
Preventive medicine
Public health
Questionnaires
Schools
Schools, Nursery
Small intestine
Statistical analysis
Trends
Japan
lactoferrin
subjective acute gastrointestinal symptoms
winter
kindergarten
diarrhea
ISSN:1660-4601, 1661-7827, 1660-4601
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Beschreibung
Zusammenfassung:This study investigated the preventive effects of lactoferrin (LF) on subjective acute gastrointestinal symptoms during the winter in a randomized, double-blinded, placebo-controlled parallel-group comparative trial. The eligible subjects were healthy adults working at kindergartens and nursery schools. We randomized the subjects to the Placebo group (0 mg/day), the Low LF group (200 mg/day), and the High LF group (600 mg/day) for 12 weeks. The prevalence of acute gastrointestinal symptoms was significantly lower in the High LF (13/112 vs. 26/116; p = 0.030) and the Low LF (13/107 vs. 26/116; p = 0.040) groups than in the Placebo group. The adjusted odds ratio for the prevalence of acute gastrointestinal symptoms was 2.78 (95% CI: 1.19–6.47) in the Placebo group compared with the High LF group. LF is useful to prevent acute gastrointestinal symptoms among childcare workers, who mainly consist of women.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1660-4601
1661-7827
1660-4601
DOI:10.3390/ijerph17249582