Isobio software: biological dose distribution and biological dose volume histogram from physical dose conversion using linear-quadratic-linear model

To develop an in-house software program that is able to calculate and generate the biological dose distribution and biological dose volume histogram by physical dose conversion using the linear-quadratic-linear (LQL) model. The Isobio software was developed using MATLAB version 2014b to calculate an...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Journal of contemporary brachytherapy Ročník 1; číslo 1; s. 44 - 51
Hlavní autoři: Jaikuna, Tanwiwat, Khadsiri, Phatchareewan, Chawapun, Nisa, Saekho, Suwit, Tharavichitkul, Ekkasit
Médium: Journal Article
Jazyk:angličtina
Vydáno: Poland Termedia Publishing House 01.02.2017
Témata:
biological dose
EQD2 software
LQL model
Original Paper
LQL model
biological dose
EQD2 software
ISSN:1689-832X, 2081-2841
On-line přístup:Získat plný text
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
Popis
Shrnutí:To develop an in-house software program that is able to calculate and generate the biological dose distribution and biological dose volume histogram by physical dose conversion using the linear-quadratic-linear (LQL) model. The Isobio software was developed using MATLAB version 2014b to calculate and generate the biological dose distribution and biological dose volume histograms. The physical dose from each voxel in treatment planning was extracted through Computational Environment for Radiotherapy Research (CERR), and the accuracy was verified by the differentiation between the dose volume histogram from CERR and the treatment planning system. An equivalent dose in 2 Gy fraction (EQD ) was calculated using biological effective dose (BED) based on the LQL model. The software calculation and the manual calculation were compared for EQD verification with pair -test statistical analysis using IBM SPSS Statistics version 22 (64-bit). Two and three-dimensional biological dose distribution and biological dose volume histogram were displayed correctly by the Isobio software. Different physical doses were found between CERR and treatment planning system (TPS) in Oncentra, with 3.33% in high-risk clinical target volume (HR-CTV) determined by D , 0.56% in the bladder, 1.74% in the rectum when determined by D , and less than 1% in Pinnacle. The difference in the EQD between the software calculation and the manual calculation was not significantly different with 0.00% at -values 0.820, 0.095, and 0.593 for external beam radiation therapy (EBRT) and 0.240, 0.320, and 0.849 for brachytherapy (BT) in HR-CTV, bladder, and rectum, respectively. The Isobio software is a feasible tool to generate the biological dose distribution and biological dose volume histogram for treatment plan evaluation in both EBRT and BT.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
ISSN:1689-832X
2081-2841
DOI:10.5114/jcb.2017.66082