Dual role of proliferating cell nuclear antigen monoubiquitination in facilitating Fanconi anemia-mediated interstrand crosslink repair

Abstract The Fanconi anemia (FA) repair pathway governs repair of highly genotoxic DNA interstrand crosslinks (ICLs) and relies on translesion synthesis (TLS). TLS is facilitated by REV1 or site-specific monoubiquitination of proliferating cell nuclear antigen (PCNA) (PCNA-Ub) at lysine 164 (K164)....

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Vydané v:	PNAS nexus Ročník 3; číslo 7; s. pgae242
Hlavní autori:	Shah, Ronak, Aslam, Muhammad Assad, Spanjaard, Aldo, de Groot, Daniel, Zürcher, Lisa M, Altelaar, Maarten, Hoekman, Liesbeth, Pritchard, Colin E J, Pilzecker, Bas, van den Berk, Paul C M, Jacobs, Heinz
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	US Oxford University Press 01.07.2024
Predmet:	Anemia Antigens Biological, Health, and Medical Sciences Care and treatment Cell cycle Crosslinking Decision making DNA repair Embryo fibroblasts Fanconi syndrome Fanconi's anemia Genetic aspects Genotoxicity Immunoprecipitation Lysine MSH2 protein MSH6 protein Mutants Mutation Physiological aspects Proliferating cell nuclear antigen Replication Spectrometry Ubiquitination Netherlands PCNA monoubiquitination mismatch repair replication stress Fanconi anemia interstrand crosslink
ISSN:	2752-6542, 2752-6542
On-line prístup:	Získať plný text
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