Low-coverage sequencing: implications for design of complex trait association studies

New sequencing technologies allow genomic variation to be surveyed in much greater detail than previously possible. While detailed analysis of a single individual typically requires deep sequencing, when many individuals are sequenced it is possible to combine shallow sequence data across individual...

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Veröffentlicht in:	Genome research Jg. 21; H. 6; S. 940
Hauptverfasser:	Li, Yun, Sidore, Carlo, Kang, Hyun Min, Boehnke, Michael, Abecasis, Gonçalo R
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.06.2011
Schlagworte:	Computational Biology - methods Genetic Variation Genome-Wide Association Study - methods Likelihood Functions Markov Chains Polymorphism, Single Nucleotide - genetics Sequence Analysis, DNA - methods
ISSN:	1549-5469, 1549-5469
Online-Zugang:	Weitere Angaben
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