Comparative accuracy and resolution assessment of two prototype proton computed tomography scanners

BackgroundImproving the accuracy of relative stopping power (RSP) in proton therapy may allow reducing range margins. Proton computed tomography (pCT) has been shown to provide state‐of‐the‐art RSP accuracy estimation, and various scanner prototypes have recently been built. The different approaches...

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Vydané v:Medical Physics Ročník 49; číslo 7; s. 4671 - 4681
Hlavní autori: Dedes, G., Drosten, H., Götz, S., Dickmann, J., Sarosiek, C., Pankuch, M., Krah, Nils, Rit, Simon, Bashkirov, V., Schulte, R.W., Johnson, R.P., Parodi, K., Dejongh, E., Landry, G.
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: United States Wiley 01.07.2022
American Association of Physicists in Medicine
Predmet:
[INFO.INFO-IM]Computer Science [cs]/Medical Imaging
Calibration
Computer Science
design choices
Image Processing, Computer-Assisted
image quality
Medical Imaging
Phantoms, Imaging
proton CT
Proton Therapy
Protons
RSP
spatial resolution
Tomography Scanners, X-Ray Computed
Tomography, X-Ray Computed
proton CT
image quality
spatial resolution
RSP
design choices
ISSN:0094-2405, 2473-4209, 2473-4209
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Popis
Shrnutí:BackgroundImproving the accuracy of relative stopping power (RSP) in proton therapy may allow reducing range margins. Proton computed tomography (pCT) has been shown to provide state‐of‐the‐art RSP accuracy estimation, and various scanner prototypes have recently been built. The different approaches used in scanner design are expected to impact spatial resolution and RSP accuracy. PurposeThe goal of this study was to perform the first direct comparison, in terms of spatial resolution and RSP accuracy, of two pCT prototype scanners installed at the same facility and by using the same image reconstruction algorithm. MethodsA phantom containing cylindrical inserts of known RSP was scanned at the phase‐II pCT prototype of the U.S. pCT collaboration and at the commercially oriented ProtonVDA scanner. Following distance‐driven binning filtered backprojection reconstruction, the radial edge spread function of high‐density inserts was used to estimate the spatial resolution. RSP accuracy was evaluated by the mean absolute percent error (MAPE) over the inserts. No direct imaging dose estimation was possible, which prevented a comparison of the two scanners in terms of RSP noise. ResultsIn terms of RSP accuracy, both scanners achieved the same MAPE of 0.72% when excluding the porous sinus insert from the evaluation. The ProtonVDA scanner reached a better overall MAPE when all inserts and the body of the phantom were accounted for (0.81%), compared to the phase‐II scanner (1.14%). The spatial resolution with the phase‐II scanner was found to be 0.61 lp/mm, while for the ProtonVDA scanner somewhat lower at 0.46 lp/mm. ConclusionsThe comparison between two prototype pCT scanners operated in the same clinical facility showed that they both fulfill the requirement of an RSP accuracy of about 1%. Their spatial resolution performance reflects the different design choices of either a scanner with full tracking capabilities (phase‐II) or of a more compact tracker system, which only provides the positions of protons but not their directions (ProtonVDA).
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0094-2405
2473-4209
2473-4209
DOI:10.1002/mp.15657