Hybrid herpes simplex virus/Epstein-Barr virus amplicon viral vectors confer enhanced transgene expression in primary human tumors and human bone marrow-derived mesenchymal stem cells

Background Herpes simplex virus type‐1 (HSV‐1) amplicon vectors are attractive tools for gene transfer because of their large DNA insert capacity, their broad host range of vector transduction and a minimal immune response as a result of the absence of helper viruses during viral packaging. However,...

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Bibliographic Details
Published in:	The journal of gene medicine Vol. 12; no. 10; pp. 848 - 858
Main Authors:	Sia, Kian Chuan, Chong, Wei Kin, Ho, Ivy A. W., Yulyana, Yulyana, Endaya, Berwini, Huynh, Hung, Lam, Paula Y. P.
Format:	Journal Article
Language:	English
Published:	Chichester, UK John Wiley & Sons, Ltd 01.10.2010 Wiley Periodicals Inc
Subjects:	Animals Brain Neoplasms - pathology Carcinoma, Hepatocellular - pathology Cell Line Cell Line, Tumor Chimera EBNA-1/oriP Epstein-Barr virus Epstein-Barr Virus Nuclear Antigens - genetics Epstein-Barr Virus Nuclear Antigens - metabolism Feasibility Studies Female Gene Expression Gene therapy Genes, Reporter Genetic Vectors Glioma - pathology HeLa Cells Helper Viruses Herpes simplex virus 1 Herpesvirus 4, Human - genetics HSV-1 amplicon Humans Liver Neoplasms - pathology long-term transgene stability Male mesenchymal stem cells Mesenchymal Stromal Cells - virology Mice Mice, Nude Mice, SCID primary human tumor Simplexvirus - genetics Transduction, Genetic Transgenes Xenograft Model Antitumor Assays - methods
ISSN:	1099-498X, 1521-2254, 1521-2254
Online Access:	Get full text
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