The Mechanism of Plasma Destruction of Enalapril and Related Metabolites in Water

A pulsed dielectric barrier discharge was used for the decomposition of enalapril, its metabolite, enalaprilat, its degradation by‐product, diketopiperazine, as well as their combination, in aqueous solution. The discharge was generated at the interface between gas and the solution which flows as a...

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Vydáno v:	Plasma processes and polymers Ročník 10; číslo 5; s. 459 - 468
Hlavní autoři:	Magureanu, Monica, Dobrin, Daniela, Mandache, Nicolae Bogdan, Bradu, Corina, Medvedovici, Andrei, Parvulescu, Vasile I.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Weinheim WILEY-VCH Verlag 01.05.2013 WILEY‐VCH Verlag Wiley-VCH Wiley Subscription Services, Inc
Témata:	Applied sciences Aqueous solutions Byproducts Crack opening displacement Degradation dielectric barrier discharge Electrodes enalapril degradation mechanism Evolution Exact sciences and technology General purification processes Metabolites Mineralization non-thermal plasma pharmaceuticals degradation in water Plasma Pollution Temporal logic Wastewaters Water treatment and pollution Drug Water treatment Emerging contaminant Dielectric barrier discharge Plasma reactor Metabolite Plasma assisted processing Non thermal plasma Non equilibrium plasma Cold plasma Enalapril enalapril degradation mechanism pharmaceuticals degradation in water Antihypertensive agent Physicochemical purification Waste water purification Degradation product non-thermal plasma Organic compounds
ISSN:	1612-8850, 1612-8869
On-line přístup:	Získat plný text
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Popis
Shrnutí:	A pulsed dielectric barrier discharge was used for the decomposition of enalapril, its metabolite, enalaprilat, its degradation by‐product, diketopiperazine, as well as their combination, in aqueous solution. The discharge was generated at the interface between gas and the solution which flows as a film on the surface of the inner electrode of the plasma reactor. The degradation mechanism of the studied compounds and the temporal evolution of the reaction intermediates were established from LC–MS analysis. A wide variety of degradation by‐products were formed; at least six new derivatives, not mentioned in literature, were observed. However, most of these by‐products were subsequently degraded to small molecules. The mineralization degree, determined from TOC and COD measurements, was approximately 40%. Non‐thermal plasma in contact with water was tested for the oxidative degradation of enalapril, enalaprilat, diketopiperazine, and their combination. The reaction intermediates were identified and their temporal evolution was followed. Based on the results, degradation pathways of these pharmaceuticals were proposed. The mineralization degree was over 40% and the residual organic matter is composed mainly of small molecules in an advanced oxidation state.
Bibliografie:	istex:2FB86B60982A1C24D93A2D9E82F55E10B8856EB0 Romanian National Authority for Scientific Research, CNCS - UEFISCDI - No. PN-II-RU-TE-2011-3-0015 ArticleID:PPAP201200146 ark:/67375/WNG-PJ6DF1CV-M ObjectType-Article-1 SourceType-Scholarly Journals-1 content type line 14 ObjectType-Article-2 ObjectType-Feature-1 content type line 23
ISSN:	1612-8850 1612-8869
DOI:	10.1002/ppap.201200146