Roles of the immune system in cancer: from tumor initiation to metastatic progression

The presence of inflammatory immune cells in human tumors raises a fundamental question in oncology: How do cancer cells avoid the destruction by immune attack? In principle, tumor development can be controlled by cytotoxic innate and adaptive immune cells; however, as the tumor develops from neopla...

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Vydané v:Genes & development Ročník 32; číslo 19-20; s. 1267
Hlavní autori: Gonzalez, Hugo, Hagerling, Catharina, Werb, Zena
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: United States 01.10.2018
Predmet:
B-Lymphocytes - immunology
Carcinoma - immunology
Carcinoma - secondary
Dendritic Cells - immunology
Disease Progression
Humans
Immunologic Surveillance
Inflammation - immunology
Killer Cells, Natural - immunology
Macrophages - immunology
Neoplasm Metastasis - immunology
Neoplasms - immunology
Neutrophils - immunology
T-Lymphocytes - immunology
disseminated tumor cells
immune cross-talk
patient-derived xenograft
cancer heterogeneity
metastasis-associated immune cells
tumor-associated macrophages
ISSN:1549-5477, 1549-5477
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Shrnutí:The presence of inflammatory immune cells in human tumors raises a fundamental question in oncology: How do cancer cells avoid the destruction by immune attack? In principle, tumor development can be controlled by cytotoxic innate and adaptive immune cells; however, as the tumor develops from neoplastic tissue to clinically detectable tumors, cancer cells evolve different mechanisms that mimic peripheral immune tolerance in order to avoid tumoricidal attack. Here, we provide an update of recent accomplishments, unifying concepts, and future challenges to study tumor-associated immune cells, with an emphasis on metastatic carcinomas.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ObjectType-Review-3
content type line 23
ISSN:1549-5477
1549-5477
DOI:10.1101/gad.314617.118