Foxl2 is required for commitment to ovary differentiation

Genetic control of female sex differentiation from a bipotential gonad in mammals is poorly understood. We find that mouse XX gonads lacking the forkhead transcription factor Foxl2 form meiotic prophase oocytes, but then activate the genetic program for somatic testis determination. Pivotal Foxl2 ac...

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Vydáno v:Human molecular genetics Ročník 14; číslo 14; s. 2053
Hlavní autoři: Ottolenghi, Chris, Omari, Shakib, Garcia-Ortiz, J Elias, Uda, Manuela, Crisponi, Laura, Forabosco, Antonino, Pilia, Giuseppe, Schlessinger, David
Médium: Journal Article
Jazyk:angličtina
Vydáno: England 15.07.2005
Témata:
Animals
Female
Forkhead Box Protein L2
Forkhead Transcription Factors - genetics
Immunohistochemistry
Mice
Microscopy, Electron
Ovary - embryology
Ovary - physiology
Ovary - ultrastructure
Sex Differentiation - genetics
ISSN:0964-6906
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Shrnutí:Genetic control of female sex differentiation from a bipotential gonad in mammals is poorly understood. We find that mouse XX gonads lacking the forkhead transcription factor Foxl2 form meiotic prophase oocytes, but then activate the genetic program for somatic testis determination. Pivotal Foxl2 action thus represses the male gene pathway at several stages of female gonadal differentiation. This suggests the possible continued involvement of sex-determining genes in maintaining ovarian function throughout female reproductive life.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0964-6906
DOI:10.1093/hmg/ddi210