Foxl2 is required for commitment to ovary differentiation

Genetic control of female sex differentiation from a bipotential gonad in mammals is poorly understood. We find that mouse XX gonads lacking the forkhead transcription factor Foxl2 form meiotic prophase oocytes, but then activate the genetic program for somatic testis determination. Pivotal Foxl2 ac...

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Published in:Human molecular genetics Vol. 14; no. 14; p. 2053
Main Authors: Ottolenghi, Chris, Omari, Shakib, Garcia-Ortiz, J Elias, Uda, Manuela, Crisponi, Laura, Forabosco, Antonino, Pilia, Giuseppe, Schlessinger, David
Format: Journal Article
Language:English
Published: England 15.07.2005
Subjects:
Animals
Female
Forkhead Box Protein L2
Forkhead Transcription Factors - genetics
Immunohistochemistry
Mice
Microscopy, Electron
Ovary - embryology
Ovary - physiology
Ovary - ultrastructure
Sex Differentiation - genetics
ISSN:0964-6906
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Abstract Genetic control of female sex differentiation from a bipotential gonad in mammals is poorly understood. We find that mouse XX gonads lacking the forkhead transcription factor Foxl2 form meiotic prophase oocytes, but then activate the genetic program for somatic testis determination. Pivotal Foxl2 action thus represses the male gene pathway at several stages of female gonadal differentiation. This suggests the possible continued involvement of sex-determining genes in maintaining ovarian function throughout female reproductive life.
AbstractList Genetic control of female sex differentiation from a bipotential gonad in mammals is poorly understood. We find that mouse XX gonads lacking the forkhead transcription factor Foxl2 form meiotic prophase oocytes, but then activate the genetic program for somatic testis determination. Pivotal Foxl2 action thus represses the male gene pathway at several stages of female gonadal differentiation. This suggests the possible continued involvement of sex-determining genes in maintaining ovarian function throughout female reproductive life.
Genetic control of female sex differentiation from a bipotential gonad in mammals is poorly understood. We find that mouse XX gonads lacking the forkhead transcription factor Foxl2 form meiotic prophase oocytes, but then activate the genetic program for somatic testis determination. Pivotal Foxl2 action thus represses the male gene pathway at several stages of female gonadal differentiation. This suggests the possible continued involvement of sex-determining genes in maintaining ovarian function throughout female reproductive life.Genetic control of female sex differentiation from a bipotential gonad in mammals is poorly understood. We find that mouse XX gonads lacking the forkhead transcription factor Foxl2 form meiotic prophase oocytes, but then activate the genetic program for somatic testis determination. Pivotal Foxl2 action thus represses the male gene pathway at several stages of female gonadal differentiation. This suggests the possible continued involvement of sex-determining genes in maintaining ovarian function throughout female reproductive life.
Author Uda, Manuela
Pilia, Giuseppe
Omari, Shakib
Garcia-Ortiz, J Elias
Crisponi, Laura
Schlessinger, David
Forabosco, Antonino
Ottolenghi, Chris
Author_xml – sequence: 1
  givenname: Chris
  surname: Ottolenghi
  fullname: Ottolenghi, Chris
  organization: Laboratory of Genetics, National Institute on Aging, Baltimore, MD 21224, USA
– sequence: 2
  givenname: Shakib
  surname: Omari
  fullname: Omari, Shakib
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  givenname: J Elias
  surname: Garcia-Ortiz
  fullname: Garcia-Ortiz, J Elias
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  givenname: Manuela
  surname: Uda
  fullname: Uda, Manuela
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  givenname: Laura
  surname: Crisponi
  fullname: Crisponi, Laura
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  surname: Forabosco
  fullname: Forabosco, Antonino
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  surname: Pilia
  fullname: Pilia, Giuseppe
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  surname: Schlessinger
  fullname: Schlessinger, David
BackLink https://www.ncbi.nlm.nih.gov/pubmed/15944199$$D View this record in MEDLINE/PubMed
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Snippet Genetic control of female sex differentiation from a bipotential gonad in mammals is poorly understood. We find that mouse XX gonads lacking the forkhead...
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SubjectTerms Animals
Female
Forkhead Box Protein L2
Forkhead Transcription Factors - genetics
Immunohistochemistry
Mice
Microscopy, Electron
Ovary - embryology
Ovary - physiology
Ovary - ultrastructure
Sex Differentiation - genetics
Title Foxl2 is required for commitment to ovary differentiation
URI https://www.ncbi.nlm.nih.gov/pubmed/15944199
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