Foxl2 is required for commitment to ovary differentiation

Genetic control of female sex differentiation from a bipotential gonad in mammals is poorly understood. We find that mouse XX gonads lacking the forkhead transcription factor Foxl2 form meiotic prophase oocytes, but then activate the genetic program for somatic testis determination. Pivotal Foxl2 ac...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Human molecular genetics Jg. 14; H. 14; S. 2053
Hauptverfasser: Ottolenghi, Chris, Omari, Shakib, Garcia-Ortiz, J Elias, Uda, Manuela, Crisponi, Laura, Forabosco, Antonino, Pilia, Giuseppe, Schlessinger, David
Format: Journal Article
Sprache:Englisch
Veröffentlicht: England 15.07.2005
Schlagworte:
Animals
Female
Forkhead Box Protein L2
Forkhead Transcription Factors - genetics
Immunohistochemistry
Mice
Microscopy, Electron
Ovary - embryology
Ovary - physiology
Ovary - ultrastructure
Sex Differentiation - genetics
ISSN:0964-6906
Online-Zugang:Weitere Angaben
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Genetic control of female sex differentiation from a bipotential gonad in mammals is poorly understood. We find that mouse XX gonads lacking the forkhead transcription factor Foxl2 form meiotic prophase oocytes, but then activate the genetic program for somatic testis determination. Pivotal Foxl2 action thus represses the male gene pathway at several stages of female gonadal differentiation. This suggests the possible continued involvement of sex-determining genes in maintaining ovarian function throughout female reproductive life.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0964-6906
DOI:10.1093/hmg/ddi210