Teaching and learning the Hodgkin-Huxley model based on software developed in NEURON’s programming language hoc
Background We present a software tool called SENB, which allows the geometric and biophysical neuronal properties in a simple computational model of a Hodgkin-Huxley (HH) axon to be changed. The aim of this work is to develop a didactic and easy-to-use computational tool in the NEURON simulation env...
Uložené v:
| Vydané v: | BMC medical education Ročník 13; číslo 1; s. 70 |
|---|---|
| Hlavní autori: | , |
| Médium: | Journal Article |
| Jazyk: | English |
| Vydavateľské údaje: |
London
BioMed Central
15.05.2013
BioMed Central Ltd Springer Nature B.V |
| Predmet: | |
| ISSN: | 1472-6920, 1472-6920 |
| On-line prístup: | Získať plný text |
| Tagy: |
Pridať tag
Žiadne tagy, Buďte prvý, kto otaguje tento záznam!
|
| Abstract | Background
We present a software tool called SENB, which allows the geometric and biophysical neuronal properties in a simple computational model of a Hodgkin-Huxley (HH) axon to be changed. The aim of this work is to develop a didactic and easy-to-use computational tool in the NEURON simulation environment, which allows graphical visualization of both the passive and active conduction parameters and the geometric characteristics of a cylindrical axon with HH properties.
Results
The SENB software offers several advantages for teaching and learning electrophysiology. First, SENB offers ease and flexibility in determining the number of stimuli. Second, SENB allows immediate and simultaneous visualization, in the same window and time frame, of the evolution of the electrophysiological variables. Third, SENB calculates parameters such as time and space constants, stimuli frequency, cellular area and volume, sodium and potassium equilibrium potentials, and propagation velocity of the action potentials. Furthermore, it allows the user to see all this information immediately in the main window. Finally, with just one click SENB can save an image of the main window as evidence.
Conclusions
The SENB software is didactic and versatile, and can be used to improve and facilitate the teaching and learning of the underlying mechanisms in the electrical activity of an axon using the biophysical properties of the squid giant axon. |
|---|---|
| AbstractList | Background We present a software tool called SENB, which allows the geometric and biophysical neuronal properties in a simple computational model of a Hodgkin-Huxley (HH) axon to be changed. The aim of this work is to develop a didactic and easy-to-use computational tool in the NEURON simulation environment, which allows graphical visualization of both the passive and active conduction parameters and the geometric characteristics of a cylindrical axon with HH properties. Results The SENB software offers several advantages for teaching and learning electrophysiology. First, SENB offers ease and flexibility in determining the number of stimuli. Second, SENB allows immediate and simultaneous visualization, in the same window and time frame, of the evolution of the electrophysiological variables. Third, SENB calculates parameters such as time and space constants, stimuli frequency, cellular area and volume, sodium and potassium equilibrium potentials, and propagation velocity of the action potentials. Furthermore, it allows the user to see all this information immediately in the main window. Finally, with just one click SENB can save an image of the main window as evidence. Conclusions The SENB software is didactic and versatile, and can be used to improve and facilitate the teaching and learning of the underlying mechanisms in the electrical activity of an axon using the biophysical properties of the squid giant axon. We present a software tool called SENB, which allows the geometric and biophysical neuronal properties in a simple computational model of a Hodgkin-Huxley (HH) axon to be changed. The aim of this work is to develop a didactic and easy-to-use computational tool in the NEURON simulation environment, which allows graphical visualization of both the passive and active conduction parameters and the geometric characteristics of a cylindrical axon with HH properties. The SENB software offers several advantages for teaching and learning electrophysiology. First, SENB offers ease and flexibility in determining the number of stimuli. Second, SENB allows immediate and simultaneous visualization, in the same window and time frame, of the evolution of the electrophysiological variables. Third, SENB calculates parameters such as time and space constants, stimuli frequency, cellular area and volume, sodium and potassium equilibrium potentials, and propagation velocity of the action potentials. Furthermore, it allows the user to see all this information immediately in the main window. Finally, with just one click SENB can save an image of the main window as evidence. The SENB software is didactic and versatile, and can be used to improve and facilitate the teaching and learning of the underlying mechanisms in the electrical activity of an axon using the biophysical properties of the squid giant axon. We present a software tool called SENB, which allows the geometric and biophysical neuronal properties in a simple computational model of a Hodgkin-Huxley (HH) axon to be changed. The aim of this work is to develop a didactic and easy-to-use computational tool in the NEURON simulation environment, which allows graphical visualization of both the passive and active conduction parameters and the geometric characteristics of a cylindrical axon with HH properties. The SENB software offers several advantages for teaching and learning electrophysiology. First, SENB offers ease and flexibility in determining the number of stimuli. Second, SENB allows immediate and simultaneous visualization, in the same window and time frame, of the evolution of the electrophysiological variables. Third, SENB calculates parameters such as time and space constants, stimuli frequency, cellular area and volume, sodium and potassium equilibrium potentials, and propagation velocity of the action potentials. Furthermore, it allows the user to see all this information immediately in the main window. Finally, with just one click SENB can save an image of the main window as evidence. The SENB software is didactic and versatile, and can be used to improve and facilitate the teaching and learning of the underlying mechanisms in the electrical activity of an axon using the biophysical properties of the squid giant axon. Background We present a software tool called SENB, which allows the geometric and biophysical neuronal properties in a simple computational model of a Hodgkin-Huxley (HH) axon to be changed. The aim of this work is to develop a didactic and easy-to-use computational tool in the NEURON simulation environment, which allows graphical visualization of both the passive and active conduction parameters and the geometric characteristics of a cylindrical axon with HH properties. Results The SENB software offers several advantages for teaching and learning electrophysiology. First, SENB offers ease and flexibility in determining the number of stimuli. Second, SENB allows immediate and simultaneous visualization, in the same window and time frame, of the evolution of the electrophysiological variables. Third, SENB calculates parameters such as time and space constants, stimuli frequency, cellular area and volume, sodium and potassium equilibrium potentials, and propagation velocity of the action potentials. Furthermore, it allows the user to see all this information immediately in the main window. Finally, with just one click SENB can save an image of the main window as evidence. Conclusions The SENB software is didactic and versatile, and can be used to improve and facilitate the teaching and learning of the underlying mechanisms in the electrical activity of an axon using the biophysical properties of the squid giant axon. Doc number: 70 Abstract Background: We present a software tool called SENB, which allows the geometric and biophysical neuronal properties in a simple computational model of a Hodgkin-Huxley (HH) axon to be changed. The aim of this work is to develop a didactic and easy-to-use computational tool in the NEURON simulation environment, which allows graphical visualization of both the passive and active conduction parameters and the geometric characteristics of a cylindrical axon with HH properties. Results: The SENB software offers several advantages for teaching and learning electrophysiology. First, SENB offers ease and flexibility in determining the number of stimuli. Second, SENB allows immediate and simultaneous visualization, in the same window and time frame, of the evolution of the electrophysiological variables. Third, SENB calculates parameters such as time and space constants, stimuli frequency, cellular area and volume, sodium and potassium equilibrium potentials, and propagation velocity of the action potentials. Furthermore, it allows the user to see all this information immediately in the main window. Finally, with just one click SENB can save an image of the main window as evidence. Conclusions: The SENB software is didactic and versatile, and can be used to improve and facilitate the teaching and learning of the underlying mechanisms in the electrical activity of an axon using the biophysical properties of the squid giant axon. We present a software tool called SENB, which allows the geometric and biophysical neuronal properties in a simple computational model of a Hodgkin-Huxley (HH) axon to be changed. The aim of this work is to develop a didactic and easy-to-use computational tool in the NEURON simulation environment, which allows graphical visualization of both the passive and active conduction parameters and the geometric characteristics of a cylindrical axon with HH properties.BACKGROUNDWe present a software tool called SENB, which allows the geometric and biophysical neuronal properties in a simple computational model of a Hodgkin-Huxley (HH) axon to be changed. The aim of this work is to develop a didactic and easy-to-use computational tool in the NEURON simulation environment, which allows graphical visualization of both the passive and active conduction parameters and the geometric characteristics of a cylindrical axon with HH properties.The SENB software offers several advantages for teaching and learning electrophysiology. First, SENB offers ease and flexibility in determining the number of stimuli. Second, SENB allows immediate and simultaneous visualization, in the same window and time frame, of the evolution of the electrophysiological variables. Third, SENB calculates parameters such as time and space constants, stimuli frequency, cellular area and volume, sodium and potassium equilibrium potentials, and propagation velocity of the action potentials. Furthermore, it allows the user to see all this information immediately in the main window. Finally, with just one click SENB can save an image of the main window as evidence.RESULTSThe SENB software offers several advantages for teaching and learning electrophysiology. First, SENB offers ease and flexibility in determining the number of stimuli. Second, SENB allows immediate and simultaneous visualization, in the same window and time frame, of the evolution of the electrophysiological variables. Third, SENB calculates parameters such as time and space constants, stimuli frequency, cellular area and volume, sodium and potassium equilibrium potentials, and propagation velocity of the action potentials. Furthermore, it allows the user to see all this information immediately in the main window. Finally, with just one click SENB can save an image of the main window as evidence.The SENB software is didactic and versatile, and can be used to improve and facilitate the teaching and learning of the underlying mechanisms in the electrical activity of an axon using the biophysical properties of the squid giant axon.CONCLUSIONSThe SENB software is didactic and versatile, and can be used to improve and facilitate the teaching and learning of the underlying mechanisms in the electrical activity of an axon using the biophysical properties of the squid giant axon. |
| ArticleNumber | 70 |
| Audience | Academic |
| Author | Zurek, Eduardo E Hernández, Oscar E |
| AuthorAffiliation | 1 Departamento de Química y Biología, Universidad del Norte, Barranquilla, Atlántico, Colombia 2 Departamento de Ingeniería de Sistemas, Universidad del Norte, Barranquilla, Atlántico, Colombia |
| AuthorAffiliation_xml | – name: 1 Departamento de Química y Biología, Universidad del Norte, Barranquilla, Atlántico, Colombia – name: 2 Departamento de Ingeniería de Sistemas, Universidad del Norte, Barranquilla, Atlántico, Colombia |
| Author_xml | – sequence: 1 givenname: Oscar E surname: Hernández fullname: Hernández, Oscar E email: ohernandezb@uninorte.edu.co organization: Departamento de Química y Biología, Universidad del Norte – sequence: 2 givenname: Eduardo E surname: Zurek fullname: Zurek, Eduardo E organization: Departamento de Ingeniería de Sistemas, Universidad del Norte |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/23675833$$D View this record in MEDLINE/PubMed |
| BookMark | eNp1ks1u3CAUha0qVfPTrrurkLrpxgkYG_CmUhQlnUpRIlXJGmG4eJzaMAE7aXZ5jb5en6S4k04nVSsWwOU7B464-9mO8w6y7C3Bh4QIdkRKXuSsLnBOaM7xi2xvU9nZWu9m-zHeYEy4oORVtltQxitB6V52ewVKLzvXIuUM6kEFN2_GJaCFN-3XzuWL6VsPD2jwBnrUqAgGeYeit-O9CoAM3EHvV6naOXRxev3l8uLH4_eIVsG3QQ3DbNcr106qBbT0-nX20qo-wpun-SC7Pju9Olnk55efPp8cn-e6FHTMldbW1goTJbSmZVPURd0wY4guCC1rbhpraksLzhgmDRVNU1EmGsF0aZkATg-yj2vf1dQMYDS4MaherkI3qPAgverk8xPXLWXr72SyqSpRJ4MPTwbB304QRzl0UUOfwoCfoiSUY1KUFS4T-v4v9MZPwaV4vyguCKnqP1SrepCdsz7dq2dTeVzRklFOMEvU4T-oNAwMnU7fb7tUfyZ4tx10k_D3JyfgaA3o4GMMYDcIwXJuIzk3ipwbJT1XcpwUeK2IiXQthK08_5H8BAWCyPM |
| Cites_doi | 10.1002/sce.20266 10.1113/jphysiol.1952.sp004764 10.3389/neuro.11.001.2009 10.1126/science.1182594 10.1080/0950069042000230709 10.4249/scholarpedia.1430 10.1007/978-1-4612-1634-6_2 10.1017/CBO9780511541612 10.1007/978-1-4615-3560-7_11 10.1136/jnnp.40.5.434 10.1113/jphysiol.1949.sp004388 10.1162/089976600300015475 |
| ContentType | Journal Article |
| Copyright | Hernández and Zurek; licensee BioMed Central Ltd. 2013 COPYRIGHT 2013 BioMed Central Ltd. 2013 Hernández and Zurek; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright © 2013 Hernández and Zurek; licensee BioMed Central Ltd. 2013 Hernández and Zurek; licensee BioMed Central Ltd. |
| Copyright_xml | – notice: Hernández and Zurek; licensee BioMed Central Ltd. 2013 – notice: COPYRIGHT 2013 BioMed Central Ltd. – notice: 2013 Hernández and Zurek; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. – notice: Copyright © 2013 Hernández and Zurek; licensee BioMed Central Ltd. 2013 Hernández and Zurek; licensee BioMed Central Ltd. |
| DBID | C6C AAYXX CITATION CGR CUY CVF ECM EIF NPM 0-V 3V. 7X7 7XB 88B 88C 88E 8FI 8FJ 8FK ABUWG AFKRA ALSLI AZQEC BENPR CCPQU CJNVE DWQXO FYUFA GHDGH GNUQQ K9. M0P M0S M0T M1P PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEDU PQEST PQQKQ PQUKI PRINS Q9U 7X8 5PM |
| DOI | 10.1186/1472-6920-13-70 |
| DatabaseName | Springer Nature OA Free Journals CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Social Sciences Premium Collection【Remote access available】 ProQuest Central (Corporate) Health & Medical Collection ProQuest Central (purchase pre-March 2016) Education Database (Alumni Edition) Healthcare Administration Database (Alumni) Medical Database (Alumni Edition) Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central UK/Ireland Social Science Premium Collection ProQuest Central Essentials - QC ProQuest Central ProQuest One Education Collection ProQuest Central Korea Proquest Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student ProQuest Health & Medical Complete (Alumni) Education Database ProQuest Health & Medical Collection Healthcare Administration Database Medical Database ProQuest Central Premium ProQuest One Academic (New) ProQuest Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Education ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China ProQuest Central Basic MEDLINE - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Publicly Available Content Database ProQuest One Education ProQuest Central Student ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Central China ProQuest Central ProQuest Health & Medical Research Collection Health Research Premium Collection Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Health & Medical Research Collection ProQuest Central (New) ProQuest Medical Library (Alumni) Social Science Premium Collection Education Collection ProQuest Central Basic ProQuest Education Journals ProQuest One Academic Eastern Edition ProQuest Health Management ProQuest Hospital Collection Health Research Premium Collection (Alumni) ProQuest Hospital Collection (Alumni) ProQuest Health & Medical Complete ProQuest Medical Library ProQuest Social Sciences Premium Collection ProQuest One Academic UKI Edition ProQuest Health Management (Alumni Edition) ProQuest One Academic ProQuest One Academic (New) ProQuest Education Journals (Alumni Edition) ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE Publicly Available Content Database MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: PIMPY name: ProQuest Publicly Available Content Database url: http://search.proquest.com/publiccontent sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine Education |
| EISSN | 1472-6920 |
| EndPage | 70 |
| ExternalDocumentID | PMC3685589 3003432651 A534637106 23675833 10_1186_1472_6920_13_70 |
| Genre | Research Support, Non-U.S. Gov't Journal Article |
| GeographicLocations | Colombia |
| GeographicLocations_xml | – name: Colombia |
| GroupedDBID | --- 0-V 0R~ 23N 2WC 4.4 53G 5GY 5VS 6J9 7X7 88E 8FI 8FJ AAFWJ AAJSJ AASML ABUWG ACGFO ACGFS ACHQT ACIHN ADBBV ADRAZ ADUKV AEAQA AENEX AFKRA AFPKN AHBYD AHMBA AHSBF AHYZX ALMA_UNASSIGNED_HOLDINGS ALSLI AMKLP AMTXH AOIJS AQUVI ARALO AZQEC BAPOH BAWUL BCNDV BENPR BFQNJ BMC BPHCQ BVXVI C6C CCPQU CJNVE CS3 DIK DU5 DWQXO E3Z EBD EBLON EBS EJD EMB EMOBN F5P FYUFA GNUQQ GROUPED_DOAJ GX1 H13 HMCUK HYE IAO IHR INH INR IPNFZ ITC IVC KQ8 M0P M0T M1P M48 M~E O5R O5S OK1 OVT P2P PGMZT PHGZM PHGZT PIMPY PJZUB PPXIY PQEDU PQQKQ PROAC PSQYO PUEGO RBZ RIG RNS ROL RPM RSV SHS SOJ SV3 TR2 UKHRP W2D WOQ WOW XSB AAYXX AFFHD CITATION ALIPV CGR CUY CVF ECM EIF NPM 3V. 7XB 8FK K9. PKEHL PQEST PQUKI PRINS Q9U 7X8 5PM |
| ID | FETCH-LOGICAL-c483t-accff9a01a8cc34b2929b6dd1c213497dbfd9f3276601b38bb5368b86c4f68e73 |
| IEDL.DBID | RSV |
| ISICitedReferencesCount | 3 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000320873300001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 1472-6920 |
| IngestDate | Tue Nov 04 01:55:54 EST 2025 Thu Oct 02 12:12:01 EDT 2025 Tue Oct 07 05:36:23 EDT 2025 Tue Nov 11 10:57:43 EST 2025 Tue Nov 04 18:21:14 EST 2025 Thu Apr 03 07:06:26 EDT 2025 Sat Nov 29 03:44:10 EST 2025 Sat Sep 06 07:22:28 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Keywords | Current Stimulus Sodium Channel Current Clamp Unmyelinated Axon Virtual Experiment |
| Language | English |
| License | http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c483t-accff9a01a8cc34b2929b6dd1c213497dbfd9f3276601b38bb5368b86c4f68e73 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 |
| OpenAccessLink | https://link.springer.com/10.1186/1472-6920-13-70 |
| PMID | 23675833 |
| PQID | 1370781159 |
| PQPubID | 42593 |
| PageCount | 1 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_3685589 proquest_miscellaneous_1370124504 proquest_journals_1370781159 gale_infotracmisc_A534637106 gale_infotracacademiconefile_A534637106 pubmed_primary_23675833 crossref_primary_10_1186_1472_6920_13_70 springer_journals_10_1186_1472_6920_13_70 |
| PublicationCentury | 2000 |
| PublicationDate | 2013-05-15 |
| PublicationDateYYYYMMDD | 2013-05-15 |
| PublicationDate_xml | – month: 05 year: 2013 text: 2013-05-15 day: 15 |
| PublicationDecade | 2010 |
| PublicationPlace | London |
| PublicationPlace_xml | – name: London – name: England |
| PublicationTitle | BMC medical education |
| PublicationTitleAbbrev | BMC Med Educ |
| PublicationTitleAlternate | BMC Med Educ |
| PublicationYear | 2013 |
| Publisher | BioMed Central BioMed Central Ltd Springer Nature B.V |
| Publisher_xml | – name: BioMed Central – name: BioMed Central Ltd – name: Springer Nature B.V |
| References | Haefner, Altoona (CR9) 2004; 26 Norris, Phillips, Smith, Gwilbert, Stange, Baker, Weler (CR7) 2008; 92 CR18 Hodgkin, Huxley, Katz (CR10) 1952; 117 CR16 Lorenz, Egelhaaf (CR2) 2008; 3 Gewaltig, Diesmann (CR11) 2007; 2 Koch (CR25) 2004 Hodgkin, Katz (CR19) 1949; 109 Av-Ron, Byrne, Baxter (CR1) 2006; 4 Velázquez, Sosa (CR5) 2009; 50 Hall, Harrington (CR8) 2008; 2 Moore, Stuart (CR4) 2004; 2 Av-Ron, Byrne, Byrne, Baxter (CR3) 2008; 3 Hines, Davison, Muller (CR22) 2009; 3 Hines, Eeckman (CR12) 1993 Hines, Carnevale (CR21) 2000; 12 Hernández, Hernández (CR17) 2012; 27 Gabbiani, Koch, Koch, Segev (CR27) 1998 CR24 Hines, Carnevale, Arbib (CR13) 1993 Carnevale, Hines (CR14) 2006 CR23 CR20 Bower, Beeman (CR15) 1998 Van den Broek (CR6) 2010; 328 Low, McLeod (CR26) 1977; 40 JM Bower (753_CR15) 1998 A Hodgkin (753_CR10) 1952; 117 F Gabbiani (753_CR27) 1998 M Hines (753_CR22) 2009; 3 S Lorenz (753_CR2) 2008; 3 MO Gewaltig (753_CR11) 2007; 2 M Hines (753_CR12) 1993 753_CR16 C Koch (753_CR25) 2004 M Hines (753_CR21) 2000; 12 O Hernández (753_CR17) 2012; 27 E Av-Ron (753_CR3) 2008; 3 P Van den Broek (753_CR6) 2010; 328 J Moore (753_CR4) 2004; 2 AC Hall (753_CR8) 2008; 2 753_CR18 SP Norris (753_CR7) 2008; 92 PA Low (753_CR26) 1977; 40 M Hines (753_CR13) 1993 A Hodgkin (753_CR19) 1949; 109 753_CR23 753_CR24 LA Haefner (753_CR9) 2004; 26 NT Carnevale (753_CR14) 2006 E Av-Ron (753_CR1) 2006; 4 I Velázquez (753_CR5) 2009; 50 753_CR20 15394322 - J Physiol. 1949 Aug;109(1-2):240-9 19198661 - Front Neuroinform. 2009 Jan 28;3:1 12991237 - J Physiol. 1952 Aug;117(4):500-44 10905805 - Neural Comput. 2000 May;12(5):995-1007 23493933 - J Undergrad Neurosci Educ. 2003 Fall;2(1):A1-7 20413489 - Science. 2010 Apr 23;328(5977):453-6 23493644 - J Undergrad Neurosci Educ. 2006 Spring;4(2):A40-52 |
| References_xml | – volume: 4 start-page: 40 issue: 2 year: 2006 end-page: 52 ident: CR1 article-title: Teaching basic principles of neuroscience with computer simulation publication-title: J Undergrad Neurosci Educ – volume: 3 start-page: 1 year: 2008 end-page: 20 ident: CR2 article-title: Curricular integration of simulations in Neuroscience instructional and technical perspectives publication-title: Brain, Mind Media – ident: CR18 – volume: 3 start-page: 1 year: 2008 end-page: 10 ident: CR3 article-title: SNNAP: A tool for teaching neuroscience publication-title: Brain, Mind Media – volume: 92 start-page: 765 year: 2008 end-page: 798 ident: CR7 article-title: Learning to read scientific text: Do elementary school commercial reading programs help? publication-title: Sci Educ doi: 10.1002/sce.20266 – ident: CR16 – volume: 117 start-page: 500 year: 1952 end-page: 544 ident: CR10 article-title: A quantitative description of membrane current and its application to conduction and excitation in nerve publication-title: J Physiol doi: 10.1113/jphysiol.1952.sp004764 – start-page: 156 year: 2004 end-page: 159 ident: CR25 article-title: Relating firing frecuency to sustained current input publication-title: Biophysics of Computation: Information Processing in Single Neurons – start-page: 1 year: 1993 end-page: 18 ident: CR13 article-title: Computer simulation methods for neurons publication-title: The Handbook of Brain Theory and Neural Networks – volume: 2 start-page: 1 year: 2008 end-page: 7 ident: CR8 article-title: Experimental methods in neuroscience: An undergraduate neuroscience laboratory courses for teaching ethical issues, laboratory techniques, experimental design, and analysis publication-title: J Undergrad Neurosci Educ – volume: 50 start-page: 4 year: 2009 end-page: 5 ident: CR5 article-title: La usabilidad del software educativo como potenciador de nuevas formas de pensamiento publication-title: Rev Iberoam Educación – volume: 3 start-page: 1 year: 2009 end-page: 12 ident: CR22 article-title: NEURON and Python publication-title: Front Neuroinformatics doi: 10.3389/neuro.11.001.2009 – volume: 328 start-page: 453 year: 2010 end-page: 456 ident: CR6 article-title: Using texts in science education: Cognitive processes and knowledge representation science publication-title: Science doi: 10.1126/science.1182594 – volume: 27 start-page: 223 year: 2012 end-page: 235 ident: CR17 article-title: Relación entre conductancias de sodio y potasio al estilo Hodgkin y Huxley y su efecto en la propagación de potenciales de acción a 40°C publication-title: Rev Salud Uninorte – volume: 26 start-page: 1653 issue: 13 year: 2004 end-page: 1674 ident: CR9 article-title: Learning by doing? Prospective elementary teachers’ developing understandings of scientific inquirí and science teaching and learning publication-title: Int J Sci Educ doi: 10.1080/0950069042000230709 – volume: 2 start-page: 1430 issue: 4 year: 2007 ident: CR11 article-title: NEST publication-title: Scholaropedia doi: 10.4249/scholarpedia.1430 – ident: CR23 – start-page: 7 year: 1998 end-page: 16 ident: CR15 article-title: Compartmental modeling publication-title: The Book of GENESIS: Exploring Realistic Neural Models with the GEneral NEural SImulation System doi: 10.1007/978-1-4612-1634-6_2 – start-page: 67 year: 2006 end-page: 75 ident: CR14 article-title: Representing neurons with a digital computer publication-title: The Neuron Book doi: 10.1017/CBO9780511541612 – start-page: 127 year: 1993 end-page: 136 ident: CR12 article-title: NEURON: a program for simulation of nerve equations publication-title: Neural Systems: Analysis and Modelin doi: 10.1007/978-1-4615-3560-7_11 – ident: CR24 – volume: 40 start-page: 434 year: 1977 end-page: 447 ident: CR26 article-title: A dynamic dendritic refractory period regulates burst discharge in the electrosensory lobe of weakly electric fish publication-title: J Neurol Neurosurg Psychiatry doi: 10.1136/jnnp.40.5.434 – volume: 2 start-page: 6 issue: 2 year: 2004 end-page: 7 ident: CR4 article-title: Neurons in action: Computer simulations with NeuroLab publication-title: J Undergrad Neurosci Educ – ident: CR20 – volume: 109 start-page: 240 year: 1949 end-page: 249 ident: CR19 article-title: The effect of temperature on the electrical activity of the giant axon of the squid publication-title: J Physiol doi: 10.1113/jphysiol.1949.sp004388 – volume: 12 start-page: 839 year: 2000 end-page: 851 ident: CR21 article-title: Expanding NEURON’s repertoire of mechanisms with NMODL publication-title: Neural Comput doi: 10.1162/089976600300015475 – start-page: 313 year: 1998 end-page: 360 ident: CR27 article-title: Principles of spike train analysis publication-title: Methods in Neuronal Modeling – start-page: 7 volume-title: The Book of GENESIS: Exploring Realistic Neural Models with the GEneral NEural SImulation System year: 1998 ident: 753_CR15 doi: 10.1007/978-1-4612-1634-6_2 – start-page: 127 volume-title: Neural Systems: Analysis and Modelin year: 1993 ident: 753_CR12 doi: 10.1007/978-1-4615-3560-7_11 – ident: 753_CR23 – volume: 92 start-page: 765 year: 2008 ident: 753_CR7 publication-title: Sci Educ doi: 10.1002/sce.20266 – volume: 50 start-page: 4 year: 2009 ident: 753_CR5 publication-title: Rev Iberoam Educación – volume: 40 start-page: 434 year: 1977 ident: 753_CR26 publication-title: J Neurol Neurosurg Psychiatry doi: 10.1136/jnnp.40.5.434 – volume: 4 start-page: 40 issue: 2 year: 2006 ident: 753_CR1 publication-title: J Undergrad Neurosci Educ – volume: 3 start-page: 1 year: 2008 ident: 753_CR2 publication-title: Brain, Mind Media – volume: 26 start-page: 1653 issue: 13 year: 2004 ident: 753_CR9 publication-title: Int J Sci Educ doi: 10.1080/0950069042000230709 – volume: 109 start-page: 240 year: 1949 ident: 753_CR19 publication-title: J Physiol doi: 10.1113/jphysiol.1949.sp004388 – start-page: 156 volume-title: Biophysics of Computation: Information Processing in Single Neurons year: 2004 ident: 753_CR25 – volume: 3 start-page: 1 year: 2008 ident: 753_CR3 publication-title: Brain, Mind Media – start-page: 67 volume-title: The Neuron Book year: 2006 ident: 753_CR14 doi: 10.1017/CBO9780511541612 – ident: 753_CR16 – ident: 753_CR18 – ident: 753_CR24 – volume: 27 start-page: 223 year: 2012 ident: 753_CR17 publication-title: Rev Salud Uninorte – ident: 753_CR20 – volume: 2 start-page: 1 year: 2008 ident: 753_CR8 publication-title: J Undergrad Neurosci Educ – volume: 2 start-page: 1430 issue: 4 year: 2007 ident: 753_CR11 publication-title: Scholaropedia doi: 10.4249/scholarpedia.1430 – volume: 3 start-page: 1 year: 2009 ident: 753_CR22 publication-title: Front Neuroinformatics doi: 10.3389/neuro.11.001.2009 – volume: 2 start-page: 6 issue: 2 year: 2004 ident: 753_CR4 publication-title: J Undergrad Neurosci Educ – start-page: 1 volume-title: The Handbook of Brain Theory and Neural Networks year: 1993 ident: 753_CR13 – volume: 117 start-page: 500 year: 1952 ident: 753_CR10 publication-title: J Physiol doi: 10.1113/jphysiol.1952.sp004764 – volume: 12 start-page: 839 year: 2000 ident: 753_CR21 publication-title: Neural Comput doi: 10.1162/089976600300015475 – start-page: 313 volume-title: Methods in Neuronal Modeling year: 1998 ident: 753_CR27 – volume: 328 start-page: 453 year: 2010 ident: 753_CR6 publication-title: Science doi: 10.1126/science.1182594 – reference: 15394322 - J Physiol. 1949 Aug;109(1-2):240-9 – reference: 23493933 - J Undergrad Neurosci Educ. 2003 Fall;2(1):A1-7 – reference: 20413489 - Science. 2010 Apr 23;328(5977):453-6 – reference: 12991237 - J Physiol. 1952 Aug;117(4):500-44 – reference: 10905805 - Neural Comput. 2000 May;12(5):995-1007 – reference: 23493644 - J Undergrad Neurosci Educ. 2006 Spring;4(2):A40-52 – reference: 19198661 - Front Neuroinform. 2009 Jan 28;3:1 |
| SSID | ssj0017831 |
| Score | 1.971214 |
| Snippet | Background
We present a software tool called SENB, which allows the geometric and biophysical neuronal properties in a simple computational model of a... We present a software tool called SENB, which allows the geometric and biophysical neuronal properties in a simple computational model of a Hodgkin-Huxley (HH)... Background We present a software tool called SENB, which allows the geometric and biophysical neuronal properties in a simple computational model of a... Doc number: 70 Abstract Background: We present a software tool called SENB, which allows the geometric and biophysical neuronal properties in a simple... |
| SourceID | pubmedcentral proquest gale pubmed crossref springer |
| SourceType | Open Access Repository Aggregation Database Index Database Publisher |
| StartPage | 70 |
| SubjectTerms | Action Potentials - physiology Anatomy Approaches to teaching and learning Basic Skills Climate Computer Simulation Computer Software Education Electrophysiology - education Environment Geometry Graphs Humans Language Learning Processes Medical Education Medical students Models, Neurological Neural networks Neurology - education Neurons Neurons - physiology Neurosciences Observation Periodicals Potassium Programming Languages Propagation Scientific Research Software Studies Syntax Teaching - methods Teaching Models Technology application Textbooks Theory of Medicine/Bioethics Undergraduate Students Visualization (Computers) |
| SummonAdditionalLinks | – databaseName: Health & Medical Collection dbid: 7X7 link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9QwEB5BQagX3pRAQUZCKhysruP4kROqENUeYMWhSHuz_Eq7QiRlH8DPx5N1lt0V4sI1tuM4M54Z2-PvA3jtQvBNlCW1pfY0hdSW6kbW1Ctex5g8ggg9iOtHNZno6bT-nDfcFjmtcrCJvaEOncc98lPGe1ya5H3fXX-nyBqFp6uZQuMm3ELabNRzNd0suJjSnGU4H6blKatUSWWd1kuMU2Qn3vJE-_Z4yyHtJ0vunZj2juj83v8O4T7czSEoOVvrzAO4EduHcOdTPmR_BN1FzrAktg0k00pckhQpknEXLr_OWjpe_UrGhPQ0OgQdYSBdSxbJpP-080jyTaz0dNaSCSYLTk4WJKeCfcOXDduk5Krzj-HL-YeL92OaeRmorzRfUut909R2xKz2nleuTCGWkyEwj_BwtQquCXXDSyXTas9x7ZzgUjstfdVIHRV_Agdt18anQEbWp_gv1CxyW6WmTnshfFPaFEfWQrsC3gwyMtdr-A3TL1u0NChOg-I0jBs1KuAEZWhwYiZBeZvvF6SOEOLKnAleSZ4CKlnA8U7NNKH8bvEgPpMn9ML8kV0BrzbF2BKT1NrYrdZ1UrgkRlUBR2ul2Xw0AuXhBbcC1I46bSogzPduSTu76uG-kSJA6NTv20Hxtj7r7__i2b-H8BwOy57VQ1AmjuFgOV_FF3Db_1jOFvOX_Rz6DS-qJNQ priority: 102 providerName: ProQuest |
| Title | Teaching and learning the Hodgkin-Huxley model based on software developed in NEURON’s programming language hoc |
| URI | https://link.springer.com/article/10.1186/1472-6920-13-70 https://www.ncbi.nlm.nih.gov/pubmed/23675833 https://www.proquest.com/docview/1370781159 https://www.proquest.com/docview/1370124504 https://pubmed.ncbi.nlm.nih.gov/PMC3685589 |
| Volume | 13 |
| WOSCitedRecordID | wos000320873300001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVADU databaseName: BioMed Central Open Access Free customDbUrl: eissn: 1472-6920 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0017831 issn: 1472-6920 databaseCode: RBZ dateStart: 20010101 isFulltext: true titleUrlDefault: https://www.biomedcentral.com/search/ providerName: BioMedCentral – providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 1472-6920 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0017831 issn: 1472-6920 databaseCode: DOA dateStart: 20010101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources customDbUrl: eissn: 1472-6920 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0017831 issn: 1472-6920 databaseCode: M~E dateStart: 20010101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre – providerCode: PRVPQU databaseName: Education Database customDbUrl: eissn: 1472-6920 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0017831 issn: 1472-6920 databaseCode: M0P dateStart: 20090101 isFulltext: true titleUrlDefault: https://search.proquest.com/education providerName: ProQuest – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 1472-6920 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0017831 issn: 1472-6920 databaseCode: 7X7 dateStart: 20090101 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: Healthcare Administration Database customDbUrl: eissn: 1472-6920 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0017831 issn: 1472-6920 databaseCode: M0T dateStart: 20090101 isFulltext: true titleUrlDefault: https://search.proquest.com/healthmanagement providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 1472-6920 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0017831 issn: 1472-6920 databaseCode: BENPR dateStart: 20090101 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Publicly Available Content Database customDbUrl: eissn: 1472-6920 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0017831 issn: 1472-6920 databaseCode: PIMPY dateStart: 20090101 isFulltext: true titleUrlDefault: http://search.proquest.com/publiccontent providerName: ProQuest – providerCode: PRVAVX databaseName: SpringerLINK Contemporary 1997-Present customDbUrl: eissn: 1472-6920 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0017831 issn: 1472-6920 databaseCode: RSV dateStart: 20011201 isFulltext: true titleUrlDefault: https://link.springer.com/search?facet-content-type=%22Journal%22 providerName: Springer Nature |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lj9MwEB4tuwhx4bG8AktlJCTgYJHE8SPHBe2qSLSKoKByihw72a0QCfQBHPkb_D1-CWPXqbbVXuDiQ23Xlj3j-SYefwPwtLLWNLVIqU6VoQipNVWNyKmRLK9rtAjcehLXt3I8VtNpXuxB0r-F8dHu_ZWkP6m9WivxMslkSkWO3k7CqEQv_YA7qhnnoL__uLk4kIolgcHnkk5bxmf3CL5gg3bjI3cuSb3tOb35H7O-BTcC0CTHa8m4DXt1e-hyNId4jkO4NgrX6nfg2yTEVBLdWhISSZwRxIZk2Nmzz7OWDlc_8fggPnEOcabPkq4lCzzEf-h5TcLbK_x11pKxCw8c__n1e0FC-NcX93f9p1Fy3pm78OH0ZPJ6SEMuBmoyxZZUG9M0uY4TrYxhWZUirKqEtYlxlHC5tFVj84alUqCHVzFVVZwJVSlhskaoWrJ7sN92bf0ASKwNYj6bJzXTGXatlOHcNKlG7JhzVUXwvN-k8uuacqP0rooSpVvO0i1nmbBSxhE8c5tYOmXEnTI6vCnAgRytVXnMWSYYgigRwdFWS1Qis13di0EZlHiBQ3gqJAR8ETzZVLueLjCtrbvVug1CJB5nEdxfS81m0o4czz1qi0BuydOmgaP23q5pZ-ee4tulBeAKx33RS9WFaV2-Fg__oe0juJ76tB6cJvwI9pfzVf0Yrprvy9liPoArcip9qQZw8OpkXLwb-G8VWI7iwpcTrCnejIpPA69_fwGtWyXy |
| linkProvider | Springer Nature |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1LbxMxEB6VFFEuvB8LBYwEKhysZte7Xu8BoQqoEjWJcghSOble29tGFbslDwp_it_IeOMNSYS49cB1_fZ-nhnb428AXuXG6MLyiKpIaIomtaKi4BnVKcusRY2QmJrEtZcOBuL4OBtuwa_mLYxzq2xkYi2oTaXdGfl-yGpeGtS-7y--URc1yt2uNiE0FrA4sj8vccs2fdf9iP_3dRQdfhp96FAfVYDqWLAZVVoXRabaoRJasziP0EDIuTGhduRmWWrywmQFi1KOe5WciTxPGBe54DouuLApw3qvwXaMYG-3YHvY7Q-_LO8tUsFCTyAUCr4fxmlEeYY7tJBRFw95RfdtaoAVFbjpnrlxR1urvsPb_9uk3YFb3sgmB4tVcRe2bHkPbvS9G8F9qEbeh5So0hAfOOOUoC1MOpU5PR-XtDP_geKS1IGCiFP1hlQlmaLSulQTS_xbM_w6LsnAuUMO9qbEO7t9dZU1B8HkrNIP4POVDPchtMqqtI-BtJVGC9dkoWUqxqK50Emii0ihpZwlIg_gTYMJebEgGJH1xkxw6eAjHXxkyGTaDmDPYUY60YPA0Mq_oMCGHImXPEhYzBmajDyA3bWcKDL0enIDF-lF1lT-wUoAL5fJrqRzwyttNV_kQYMwaccBPFqAdNlpRwXonvAFkK7Bd5nBEZmvp5Tjs5rQ3AVBSAS2-7YB-kq3_j4XT_49hBew0xn1e7LXHRw9hZtRHcMkoWGyC63ZZG6fwXX9fTaeTp77FUzg5Krx_xuP94RI |
| linkToPdf | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3NbtQwELZQQRUXfgqUQAEjIQEHq5s4_smxAlaLKFEFBfVmObbTrhBO2ewCR16D1-NJGCfOqln1grjGduzYM56Z-PM3CD2rrDW14xnRmTQEXGpNZM0LYgQtnAOLwGxH4nooylKenBRHEZvTDmj34Uiyv9MQWJr8cv_c1r2KS76f5iIjvIDIJ6VEQMR-NYcwJiC6Pnz8vD5EEJKmkc3nkkYjQ7S5HV-wR5tYyY0D084OTW_-5xfcQjeiA4oPeom5ja44vxNyN0ecxw7afh-P2--gb8cRa4m1tzgmmDjF4DPiWWNPv8w9ma1-wraCu4Q6OJhEixuPW9jcf-iFw_FOFjyde1wG2GD559fvFkdY2NfwuuGXKT5rzF30afrm-NWMxBwNxOSSLok2pq4LPUm1NIbmVQbuVsWtTU2giiuErWpb1DQTHCK_isqqYpTLSnKT11w6Qe-hLd94dx_hiTbgC9oidVTn0LSShjFTZxp8yoLJKkEvhgVT5z0Vh-pCGMlVmE4VplOlVIlJgp6HBVVBSWHVjI53DaCjQHelDhjNOQXniidob1QTlMuMiweRUFG5W-iio0gCRzBBT9fFoWUArHnXrPo64DqxSZ6g3V6C1oMOpHnhsluCxEi21hUC5fe4xM_POurvkC6ASej35SBhF4Z1-Vw8-Ie6T9D20eupOnxbvnuIrmdd5g9GUraHtpaLlXuErpnvy3m7eNwp2l_NDynK |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Teaching+and+learning+the+Hodgkin-Huxley+model+based+on+software+developed+in+NEURON%E2%80%99s+programming+language+hoc&rft.jtitle=BMC+medical+education&rft.au=Hern%C3%A1ndez%2C+Oscar+E&rft.au=Zurek%2C+Eduardo+E&rft.date=2013-05-15&rft.pub=BioMed+Central&rft.eissn=1472-6920&rft.volume=13&rft.issue=1&rft_id=info:doi/10.1186%2F1472-6920-13-70&rft.externalDocID=10_1186_1472_6920_13_70 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1472-6920&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1472-6920&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1472-6920&client=summon |