Erucin, a Natural Isothiocyanate, Prevents Polyglutamine-Induced Toxicity in Caenorhabditis elegans via aak-2/AMPK and daf-16/FOXO Signaling

Several neurodegenerative diseases (NDDs), such as Huntington’s disease, six of the spinocerebellar ataxias, dentatorubral-pallidoluysian atrophy, and spinobulbar muscular atrophy, are caused by abnormally long polyglutamine (polyQ) tracts. Natural compounds capable of alleviating polyQ-induced toxi...

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Bibliographic Details
Published in:	International journal of molecular sciences Vol. 25; no. 22; p. 12220
Main Authors:	Balducci, Martina, Pérez, Julia Tortajada, del Río, Cristina Trujillo, Pérez, Mar Collado, Carranza, Andrea del Valle, Gomez Escribano, Ana Pilar, Vázquez-Manrique, Rafael P., Tarozzi, Andrea
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 14.11.2024 MDPI
Subjects:	Aggregates AMP-Activated Protein Kinases - metabolism Animals Caenorhabditis elegans - drug effects Caenorhabditis elegans - metabolism Caenorhabditis elegans Proteins - genetics Caenorhabditis elegans Proteins - metabolism Cyclic adenylic acid Degeneration Disease prevention Forkhead Transcription Factors - genetics Forkhead Transcription Factors - metabolism Genomes Glutamine Health aspects Human subjects Huntingtons disease Isothiocyanates - pharmacology Kinases Nematodes Nervous system Organosulfur compounds Peptides - metabolism Peptides - pharmacology Physiological aspects Protein kinases Proteins Signal transduction Signal Transduction - drug effects Sulfides Sulfoxides - pharmacology Thiocyanates Toxicity Transcription factors Worms Young adults Spain Caenorhabditis elegans AMPK erucin neuroprotection polyQ toxicity daf-16/FOXO
ISSN:	1422-0067, 1661-6596, 1422-0067
Online Access:	Get full text
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