MicroRNA-24 promotes 3T3-L1 adipocyte differentiation by directly targeting the MAPK7 signaling

Over the past years, MicroRNAs (miRNAs) act as a vital role in harmony with gene regulation and maintaining cellular homeostasis. It is well testified that miRNAshave been involved in numerous physiological and pathological processes, including embryogenesis, cell fate decision, and cellular differe...

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Published in:	Biochemical and biophysical research communications Vol. 474; no. 1; pp. 76 - 82
Main Authors:	Jin, Min, Wu, Yutao, Wang, Jing, Chen, Jian, Huang, Yiting, Rao, Jinpeng, Feng, Chun
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 20.05.2016
Subjects:	3T3-L1 adipocyte 3T3-L1 Cells 60 APPLIED LIFE SCIENCES adipocytes Adipocytes - cytology Adipocytes - physiology adipogenesis Adipogenesis - physiology Animals binding proteins CELL CYCLE Cell Differentiation - physiology CELL PROLIFERATION Cell Proliferation - physiology Differentiation embryogenesis Gene Expression Regulation, Developmental - physiology GENE REGULATION genes HOMEOSTASIS MAPK7 Mice microRNA MicroRNA-24 MicroRNAs - metabolism mitogen-activated protein kinase Mitogen-Activated Protein Kinase 7 - metabolism peroxisome proliferator-activated receptors RECEPTORS signal transduction SIGNALS STEROLS TRANSCRIPTION TRANSCRIPTION FACTORS triacylglycerols TRIGLYCERIDES MAPK7 Differentiation MicroRNA-24 3T3-L1 adipocyte
ISSN:	0006-291X, 1090-2104
Online Access:	Get full text
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Abstract	Over the past years, MicroRNAs (miRNAs) act as a vital role in harmony with gene regulation and maintaining cellular homeostasis. It is well testified that miRNAshave been involved in numerous physiological and pathological processes, including embryogenesis, cell fate decision, and cellular differentiation. Adipogenesis is an organized process of cellular differentiation by which pre-adipocytes differentiate towards mature adipocytes, and it is tightly modulated by a series of transcription factors such as peroxisome proliferator-activated receptor γ (PPAR-γ) and sterol regulatory-element binding proteins 1 (SREBP1). However, the molecular mechanisms underlying the connection between miRNAs and adipogenesis-related transcription factors remain obscure. In this study, we unveiled that miR- 24 was remarkably upregulated during 3T3-L1 adipogenesis. Overexpression of miR-24 significantly promoted 3T3-L1 adipogenesis, as evidenced by its ability to increase the expression of PPAR-γ and SREBP1, lipid droplet formation and triglyceride (TG) accumulation. Furthermore, we found that neither ectopic expression of miR-24nor miR-24 inhibitor affect cell proliferation and cell cycle progression. Finally, we demonstrated that miR-24 plays the modulational role by directly repressing MAPK7, a key number in the MAPK signaling pathway. These data indicate that miR-24 is a novel positive regulator of adipocyte differentiation by targeting MAPK7, which provides new insights into the molecular mechanism of miRNA-mediated cellular differentiation. •We firstly found miR-24 was upregulated in 3T3-L1 pre-adipocytes differentiation.•miR-24 promoted 3T3-L1 pre-adipocytes differentiation while silencing the expression of miR-24 had an opposite function.•miR-24 regulated 3T3-L1 differentiation by directly targeting MAPK7 signaling pathway.•miR-24did not affect 3T3-L1 pre-adipocytes cellular proliferation.
AbstractList	Over the past years, MicroRNAs (miRNAs) act as a vital role in harmony with gene regulation and maintaining cellular homeostasis. It is well testified that miRNAshave been involved in numerous physiological and pathological processes, including embryogenesis, cell fate decision, and cellular differentiation. Adipogenesis is an organized process of cellular differentiation by which pre-adipocytes differentiate towards mature adipocytes, and it is tightly modulated by a series of transcription factors such as peroxisome proliferator-activated receptor γ (PPAR-γ) and sterol regulatory-element binding proteins 1 (SREBP1). However, the molecular mechanisms underlying the connection between miRNAs and adipogenesis-related transcription factors remain obscure. In this study, we unveiled that miR- 24 was remarkably upregulated during 3T3-L1 adipogenesis. Overexpression of miR-24 significantly promoted 3T3-L1 adipogenesis, as evidenced by its ability to increase the expression of PPAR-γ and SREBP1, lipid droplet formation and triglyceride (TG) accumulation. Furthermore, we found that neither ectopic expression of miR-24nor miR-24 inhibitor affect cell proliferation and cell cycle progression. Finally, we demonstrated that miR-24 plays the modulational role by directly repressing MAPK7, a key number in the MAPK signaling pathway. These data indicate that miR-24 is a novel positive regulator of adipocyte differentiation by targeting MAPK7, which provides new insights into the molecular mechanism of miRNA-mediated cellular differentiation. -- Highlights: •We firstly found miR-24 was upregulated in 3T3-L1 pre-adipocytes differentiation. •miR-24 promoted 3T3-L1 pre-adipocytes differentiation while silencing the expression of miR-24 had an opposite function. •miR-24 regulated 3T3-L1 differentiation by directly targeting MAPK7 signaling pathway. •miR-24did not affect 3T3-L1 pre-adipocytes cellular proliferation. Over the past years, MicroRNAs (miRNAs) act as a vital role in harmony with gene regulation and maintaining cellular homeostasis. It is well testified that miRNAshave been involved in numerous physiological and pathological processes, including embryogenesis, cell fate decision, and cellular differentiation. Adipogenesis is an organized process of cellular differentiation by which pre-adipocytes differentiate towards mature adipocytes, and it is tightly modulated by a series of transcription factors such as peroxisome proliferator-activated receptor γ (PPAR-γ) and sterol regulatory-element binding proteins 1 (SREBP1). However, the molecular mechanisms underlying the connection between miRNAs and adipogenesis-related transcription factors remain obscure. In this study, we unveiled that miR- 24 was remarkably upregulated during 3T3-L1 adipogenesis. Overexpression of miR-24 significantly promoted 3T3-L1 adipogenesis, as evidenced by its ability to increase the expression of PPAR-γ and SREBP1, lipid droplet formation and triglyceride (TG) accumulation. Furthermore, we found that neither ectopic expression of miR-24nor miR-24 inhibitor affect cell proliferation and cell cycle progression. Finally, we demonstrated that miR-24 plays the modulational role by directly repressing MAPK7, a key number in the MAPK signaling pathway. These data indicate that miR-24 is a novel positive regulator of adipocyte differentiation by targeting MAPK7, which provides new insights into the molecular mechanism of miRNA-mediated cellular differentiation. Over the past years, MicroRNAs (miRNAs) act as a vital role in harmony with gene regulation and maintaining cellular homeostasis. It is well testified that miRNAshave been involved in numerous physiological and pathological processes, including embryogenesis, cell fate decision, and cellular differentiation. Adipogenesis is an organized process of cellular differentiation by which pre-adipocytes differentiate towards mature adipocytes, and it is tightly modulated by a series of transcription factors such as peroxisome proliferator-activated receptor γ (PPAR-γ) and sterol regulatory-element binding proteins 1 (SREBP1). However, the molecular mechanisms underlying the connection between miRNAs and adipogenesis-related transcription factors remain obscure. In this study, we unveiled that miR- 24 was remarkably upregulated during 3T3-L1 adipogenesis. Overexpression of miR-24 significantly promoted 3T3-L1 adipogenesis, as evidenced by its ability to increase the expression of PPAR-γ and SREBP1, lipid droplet formation and triglyceride (TG) accumulation. Furthermore, we found that neither ectopic expression of miR-24nor miR-24 inhibitor affect cell proliferation and cell cycle progression. Finally, we demonstrated that miR-24 plays the modulational role by directly repressing MAPK7, a key number in the MAPK signaling pathway. These data indicate that miR-24 is a novel positive regulator of adipocyte differentiation by targeting MAPK7, which provides new insights into the molecular mechanism of miRNA-mediated cellular differentiation. •We firstly found miR-24 was upregulated in 3T3-L1 pre-adipocytes differentiation.•miR-24 promoted 3T3-L1 pre-adipocytes differentiation while silencing the expression of miR-24 had an opposite function.•miR-24 regulated 3T3-L1 differentiation by directly targeting MAPK7 signaling pathway.•miR-24did not affect 3T3-L1 pre-adipocytes cellular proliferation.
Author	Wu, Yutao Rao, Jinpeng Jin, Min Feng, Chun Chen, Jian Wang, Jing Huang, Yiting
Author_xml	– sequence: 1 givenname: Min surname: Jin fullname: Jin, Min email: min_jin@zju.edu.cn organization: Division of Reproductive Medicine & Infertility, The Second Affiliated Hospital, School of Medicine, Zhejiang University, 88#, Jiefang Rd., Hangzhou, Zhejiang, 310009, China – sequence: 2 givenname: Yutao surname: Wu fullname: Wu, Yutao organization: School of Medicine, Zhejiang University, 288# Yuhangtang Rd, Hangzhou, Zhejiang, 310003, China – sequence: 3 givenname: Jing surname: Wang fullname: Wang, Jing organization: School of Medicine, Zhejiang University, 288# Yuhangtang Rd, Hangzhou, Zhejiang, 310003, China – sequence: 4 givenname: Jian surname: Chen fullname: Chen, Jian organization: Division of Reproductive Medicine & Infertility, The Second Affiliated Hospital, School of Medicine, Zhejiang University, 88#, Jiefang Rd., Hangzhou, Zhejiang, 310009, China – sequence: 5 givenname: Yiting surname: Huang fullname: Huang, Yiting organization: Division of Reproductive Medicine & Infertility, The Second Affiliated Hospital, School of Medicine, Zhejiang University, 88#, Jiefang Rd., Hangzhou, Zhejiang, 310009, China – sequence: 6 givenname: Jinpeng surname: Rao fullname: Rao, Jinpeng organization: Division of Reproductive Medicine & Infertility, The Second Affiliated Hospital, School of Medicine, Zhejiang University, 88#, Jiefang Rd., Hangzhou, Zhejiang, 310009, China – sequence: 7 givenname: Chun surname: Feng fullname: Feng, Chun organization: Division of Reproductive Medicine & Infertility, The Second Affiliated Hospital, School of Medicine, Zhejiang University, 88#, Jiefang Rd., Hangzhou, Zhejiang, 310009, China
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Keywords	MAPK7 Differentiation MicroRNA-24 3T3-L1 adipocyte
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Snippet	Over the past years, MicroRNAs (miRNAs) act as a vital role in harmony with gene regulation and maintaining cellular homeostasis. It is well testified that...
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SubjectTerms	3T3-L1 adipocyte 3T3-L1 Cells 60 APPLIED LIFE SCIENCES adipocytes Adipocytes - cytology Adipocytes - physiology adipogenesis Adipogenesis - physiology Animals binding proteins CELL CYCLE Cell Differentiation - physiology CELL PROLIFERATION Cell Proliferation - physiology Differentiation embryogenesis Gene Expression Regulation, Developmental - physiology GENE REGULATION genes HOMEOSTASIS MAPK7 Mice microRNA MicroRNA-24 MicroRNAs - metabolism mitogen-activated protein kinase Mitogen-Activated Protein Kinase 7 - metabolism peroxisome proliferator-activated receptors RECEPTORS signal transduction SIGNALS STEROLS TRANSCRIPTION TRANSCRIPTION FACTORS triacylglycerols TRIGLYCERIDES
Title	MicroRNA-24 promotes 3T3-L1 adipocyte differentiation by directly targeting the MAPK7 signaling
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