Black Cumin (Nigella sativa L.): A Comprehensive Review on Phytochemistry, Health Benefits, Molecular Pharmacology, and Safety

Mounting evidence support the potential benefits of functional foods or nutraceuticals for human health and diseases. Black cumin (Nigella sativa L.), a highly valued nutraceutical herb with a wide array of health benefits, has attracted growing interest from health-conscious individuals, the scient...

Celý popis

Uloženo v:

Podrobná bibliografie
Vydáno v:	Nutrients Ročník 13; číslo 6; s. 1784
Hlavní autoři:	Hannan, Md. Abdul, Rahman, Md. Ataur, Sohag, Abdullah Al Mamun, Uddin, Md. Jamal, Dash, Raju, Sikder, Mahmudul Hasan, Rahman, Md. Saidur, Timalsina, Binod, Munni, Yeasmin Akter, Sarker, Partha Protim, Alam, Mahboob, Mohibbullah, Md, Haque, Md. Nazmul, Jahan, Israt, Hossain, Md. Tahmeed, Afrin, Tania, Rahman, Md. Mahbubur, Tahjib-Ul-Arif, Md, Mitra, Sarmistha, Oktaviani, Diyah Fatimah, Khan, Md Kawsar, Choi, Ho Jin, Moon, Il Soo, Kim, Bonglee
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Basel MDPI AG 24.05.2021 MDPI
Témata:	antidotes Asthma Back pain bioactive compounds Bronchitis Cancer cell viability dietary supplements Drug delivery systems Drugs Egyptian civilization energy metabolism Essential oils Food Functional foods Functional foods & nutraceuticals human health Hypertension immunity inflammation Medicine Nanotechnology Natural foods Nigella sativa Oils & fats oxidative stress pharmacokinetics Pharmacology Physiological aspects Phytochemicals Phytochemistry Review Rheumatism Seeds Sterols thymoquinone Vehicles Bangladesh South Korea Saudi Arabia Iran Egypt Africa India
ISSN:	2072-6643, 2072-6643
On-line přístup:	Získat plný text
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!

Popis
Shrnutí:	Mounting evidence support the potential benefits of functional foods or nutraceuticals for human health and diseases. Black cumin (Nigella sativa L.), a highly valued nutraceutical herb with a wide array of health benefits, has attracted growing interest from health-conscious individuals, the scientific community, and pharmaceutical industries. The pleiotropic pharmacological effects of black cumin, and its main bioactive component thymoquinone (TQ), have been manifested by their ability to attenuate oxidative stress and inflammation, and to promote immunity, cell survival, and energy metabolism, which underlie diverse health benefits, including protection against metabolic, cardiovascular, digestive, hepatic, renal, respiratory, reproductive, and neurological disorders, cancer, and so on. Furthermore, black cumin acts as an antidote, mitigating various toxicities and drug-induced side effects. Despite significant advances in pharmacological benefits, this miracle herb and its active components are still far from their clinical application. This review begins with highlighting the research trends in black cumin and revisiting phytochemical profiles. Subsequently, pharmacological attributes and health benefits of black cumin and TQ are critically reviewed. We overview molecular pharmacology to gain insight into the underlying mechanism of health benefits. Issues related to pharmacokinetic herb–drug interactions, drug delivery, and safety are also addressed. Identifying knowledge gaps, our current effort will direct future research to advance potential applications of black cumin and TQ in health and diseases.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23 These authors contributed equally to the work.
ISSN:	2072-6643 2072-6643
DOI:	10.3390/nu13061784