Combined IL-21-primed polyclonal CTL plus CTLA4 blockade controls refractory metastatic melanoma in a patient

Adoptive transfer of peripheral blood-derived, melanoma-reactive CD8(+) cytotoxic T lymphocytes (CTLs) alone is generally insufficient to eliminate bulky tumors. Similarly, monotherapy with anti-CTLA4 infrequently yields sustained remissions in patients with metastatic melanoma. We postulated that a...

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Vydané v:	The Journal of experimental medicine Ročník 213; číslo 7; s. 1133
Hlavní autori:	Chapuis, Aude G, Lee, Sylvia M, Thompson, John A, Roberts, Ilana M, Margolin, Kim A, Bhatia, Shailender, Sloan, Heather L, Lai, Ivy, Wagener, Felecia, Shibuya, Kendall, Cao, Jianhong, Wolchok, Jedd D, Greenberg, Philip D, Yee, Cassian
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 27.06.2016
Predmet:	Adoptive Transfer - methods CD8-Positive T-Lymphocytes - transplantation CTLA-4 Antigen - immunology Female Humans Interleukins - immunology Male Melanoma - immunology Melanoma - therapy Middle Aged Neoplasm Metastasis
ISSN:	1540-9538, 1540-9538
On-line prístup:	Zistit podrobnosti o prístupe
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