Combined IL-21-primed polyclonal CTL plus CTLA4 blockade controls refractory metastatic melanoma in a patient

Adoptive transfer of peripheral blood-derived, melanoma-reactive CD8(+) cytotoxic T lymphocytes (CTLs) alone is generally insufficient to eliminate bulky tumors. Similarly, monotherapy with anti-CTLA4 infrequently yields sustained remissions in patients with metastatic melanoma. We postulated that a...

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Veröffentlicht in:	The Journal of experimental medicine Jg. 213; H. 7; S. 1133
Hauptverfasser:	Chapuis, Aude G, Lee, Sylvia M, Thompson, John A, Roberts, Ilana M, Margolin, Kim A, Bhatia, Shailender, Sloan, Heather L, Lai, Ivy, Wagener, Felecia, Shibuya, Kendall, Cao, Jianhong, Wolchok, Jedd D, Greenberg, Philip D, Yee, Cassian
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 27.06.2016
Schlagworte:	Adoptive Transfer - methods CD8-Positive T-Lymphocytes - transplantation CTLA-4 Antigen - immunology Female Humans Interleukins - immunology Male Melanoma - immunology Melanoma - therapy Middle Aged Neoplasm Metastasis
ISSN:	1540-9538, 1540-9538
Online-Zugang:	Weitere Angaben
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