Cognitive and clinical outcomes of homocysteine-lowering B-vitamin treatment in mild cognitive impairment: a randomized controlled trial

Background Homocysteine is a risk factor for Alzheimer's disease. In the first report on the VITACOG trial, we showed that homocysteine‐lowering treatment with B vitamins slows the rate of brain atrophy in mild cognitive impairment (MCI). Here we report the effect of B vitamins on cognitive and...

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Bibliographic Details
Published in:	International journal of geriatric psychiatry Vol. 27; no. 6; pp. 592 - 600
Main Authors:	de Jager, Celeste A., Oulhaj, Abderrahim, Jacoby, Robin, Refsum, Helga, Smith, A. David
Format:	Journal Article
Language:	English
Published:	Chichester, UK John Wiley & Sons, Ltd 01.06.2012 Psychology Press Wiley Subscription Services, Inc
Subjects:	Aged Aged, 80 and over Alzheimer's disease Biological and medical sciences Brain clinical dementia rating Clinical outcomes Clinical trials cobalamin Cognition - drug effects Cognition Disorders - blood Cognition Disorders - drug therapy Cognition Disorders - physiopathology cognitive decline Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Double-Blind Method Executive Function - drug effects Female folate Folic Acid - blood Folic Acid - therapeutic use General aspects Geriatric psychiatry Geriatrics Homocysteine Homocysteine - blood Humans Linear Models Male Medical sciences Memory - drug effects mild cognitive impairment Neurology Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry pyridoxine Risk factors Vitamin B Vitamin B 12 - blood Vitamin B 12 - therapeutic use Vitamin B 6 - blood Vitamin B 6 - therapeutic use Vitamin B Complex - blood Vitamin B Complex - therapeutic use Prognosis Cognitive disorder Cognition B-Vitamins cognitive decline Folic acid Folate Intellectual deterioration Randomization cobalamin Homocystein Clinical trial Evolution Degenerative disease Human homocysteine Thiol Controlled therapeutic trial Pyridoxine Sulfur containing aminoacid Gerontology Treatment clinical dementia rating Cobalamine mild cognitive impairment Elderly Psychiatry Dementia Geriatrics
ISSN:	0885-6230, 1099-1166, 1099-1166
Online Access:	Get full text
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