Early skeletal muscle deconditioning and reduced exercise capacity during (neo)adjuvant chemotherapy in patients with breast cancer

Background Fatigue is a hallmark of breast cancer and is associated with skeletal muscle deconditioning. If cancer‐related fatigue occurs early during chemotherapy (CT), the development of skeletal muscle deconditioning and its effect on exercise capacity remain unclear. The aim of this study was to...

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Veröffentlicht in:Cancer Jg. 129; H. 2; S. 215 - 225
Hauptverfasser: Mallard, Joris, Hucteau, Elyse, Schott, Roland, Trensz, Philippe, Pflumio, Carole, Kalish‐Weindling, Michal, Favret, Fabrice, Pivot, Xavier, Hureau, Thomas J., Pagano, Allan F.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States Wiley Subscription Services, Inc 15.01.2023
Wiley
John Wiley and Sons Inc
Schlagworte:
Bioelectricity
Body composition
Breast cancer
Breast Neoplasms - drug therapy
Cancer
cancer‐related fatigue
Chemotherapy
Chemotherapy, Adjuvant - adverse effects
Deconditioning
Exercise
exercise capacity
Exercise Tolerance
Fatigue
Female
Hand Strength - physiology
Humans
Knee
Life Sciences
muscle atrophy
Muscle contraction
muscle fatigue
muscle force
Muscle, Skeletal
Muscles
Muscular fatigue
Musculoskeletal system
Oncology
Original
ORIGINAL ARTICLES
Physical activity
Physical fitness
Physical training
Quality of Life
Skeletal muscle
exercise capacity
muscle force
cancer-related fatigue
muscle atrophy
muscle fatigue
ISSN:0008-543X, 1097-0142, 1097-0142
Online-Zugang:Volltext
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Zusammenfassung:Background Fatigue is a hallmark of breast cancer and is associated with skeletal muscle deconditioning. If cancer‐related fatigue occurs early during chemotherapy (CT), the development of skeletal muscle deconditioning and its effect on exercise capacity remain unclear. The aim of this study was to investigate the evolution of skeletal muscle deconditioning and exercise capacity in patients with early‐stage breast cancer during CT. Methods Patients with breast cancer had a visit before undergoing CT, at 8 weeks, and at the end of chemotherapy (post‐CT). Body composition was determined through bioelectrical impedance analysis. Knee extensor, handgrip muscle force and fatigue was quantified by performing maximal voluntary isometric contractions and exercise capacity using the 6‐min walking test. Questionnaires were also administered to evaluate quality of life, cancer‐related fatigue, and physical activity level. Results Among the 100 patients, reductions were found in muscle mass (−2.3%, p = .002), exercise capacity (−6.7%, p < .001), and knee extensor force (−4.9%, p < .001) post‐CT, which occurred within the first 8 weeks of treatment with no further decrease thereafter. If muscle fatigue did not change, handgrip muscle force decreased post‐CT only (−2.5%, p = .001), and exercise capacity continued to decrease between 8 weeks and post‐CT (−4.6%, p < .001). Quality of life and cancer‐related fatigue were impaired after 8 weeks (p < .001) and remained stable thereafter, whereas the physical activity level remained stable during chemotherapy. Conclusions Similar to cancer‐related fatigue, skeletal muscle deconditioning and reduced exercise capacity occurred early during breast cancer CT. Thus, it appears essential to prevent these alterations through exercise training implemented during CT. Using measurements obtained before, during, and after chemotherapy in patients with early‐stage breast cancer, it is highlighted that skeletal muscle deconditioning and decrease in exercise capacity appeared early during the treatment. These findings support the significance of prescribing exercise training as supportive care during chemotherapy to prevent these harmful side effects.
Bibliographie:Joris Mallard and Elyse Hucteau contributed equally to this work.
Thomas J. Hureau and Allan F. Pagano contributed equally to this work.
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ISSN:0008-543X
1097-0142
1097-0142
DOI:10.1002/cncr.34533