Friedreich's ataxia–associated GAA repeats induce replication-fork reversal and unusual molecular junctions

Friedreich's ataxia is one of several hereditary neurodegenerative disorders caused expansion of trinucleotide repeats, but the mechanism of their genomic propagation is unknown. A new plasmid-based system to probe human replicative intermediates reveals that GAA/TTC repeats interfere with repl...

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Bibliographic Details
Published in:	Nature structural & molecular biology Vol. 20; no. 4; pp. 486 - 494
Main Authors:	Follonier, Cindy, Oehler, Judith, Herrador, Raquel, Lopes, Massimo
Format:	Journal Article
Language:	English
Published:	New York Nature Publishing Group US 01.04.2013 Nature Publishing Group
Subjects:	631/337/151 631/378/1689/2014 631/45/535 Ataxia Biochemistry Biological Microscopy Care and treatment Crystal structure DNA Replication Electrophoresis Friedreich Ataxia - genetics Genetic aspects Genetic disorders Humans Life Sciences Membrane Biology Molecular biology Neurodegeneration Plasmids Protein Structure Repetitive Sequences, Nucleic Acid Signal transduction Switzerland
ISSN:	1545-9993, 1545-9985, 1545-9985
Online Access:	Get full text
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