Friedreich's ataxia–associated GAA repeats induce replication-fork reversal and unusual molecular junctions

Friedreich's ataxia is one of several hereditary neurodegenerative disorders caused expansion of trinucleotide repeats, but the mechanism of their genomic propagation is unknown. A new plasmid-based system to probe human replicative intermediates reveals that GAA/TTC repeats interfere with repl...

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Veröffentlicht in:	Nature structural & molecular biology Jg. 20; H. 4; S. 486 - 494
Hauptverfasser:	Follonier, Cindy, Oehler, Judith, Herrador, Raquel, Lopes, Massimo
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	New York Nature Publishing Group US 01.04.2013 Nature Publishing Group
Schlagworte:	631/337/151 631/378/1689/2014 631/45/535 Ataxia Biochemistry Biological Microscopy Care and treatment Crystal structure DNA Replication Electrophoresis Friedreich Ataxia - genetics Genetic aspects Genetic disorders Humans Life Sciences Membrane Biology Molecular biology Neurodegeneration Plasmids Protein Structure Repetitive Sequences, Nucleic Acid Signal transduction Switzerland
ISSN:	1545-9993, 1545-9985, 1545-9985
Online-Zugang:	Volltext
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