Immunological Mechanisms Responsible for Radiation-Induced Abscopal Effect

Radiotherapy has been used for more than a hundred years as a local tumor treatment. The occurrence of systemic antitumor effects manifesting as regression of tumors outside of the irradiated field (abscopal effect) was occasionally observed but deemed too rare and unpredictable to be a therapeutic...

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Bibliographic Details
Published in:	Trends in immunology Vol. 39; no. 8; pp. 644 - 655
Main Authors:	Rodríguez-Ruiz, María E., Vanpouille-Box, Claire, Melero, Ignacio, Formenti, Silvia Chiara, Demaria, Sandra
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01.08.2018 Elsevier Limited
Subjects:	abscopal effect Animals Antitumor activity antitumor immunity Apoptosis Breast cancer Cancer Cancer therapies Combined Modality Therapy Deoxyribonucleic acid DNA DNA damage Humans Immune checkpoint Immune system Immunology Immunotherapy Immunotherapy - methods ionizing radiation Kinases Lymphocyte Activation Lymphocytes Lymphocytes T Mutation Neoplasm Metastasis Neoplasms - radiotherapy Proteins Radiation therapy Radiotherapy - methods T-Lymphocytes - immunology Tumor Burden tumor microenvironment Tumors abscopal effect tumor microenvironment antitumor immunity DNA damage ionizing radiation immunotherapy
ISSN:	1471-4906, 1471-4981, 1471-4981
Online Access:	Get full text
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