15q11-13 GABAA receptor genes are normally biallelically expressed in brain yet are subject to epigenetic dysregulation in autism-spectrum disorders

Human chromosome 15q11-13 is a complex locus containing imprinted genes as well as a cluster of three GABA(A) receptor subunit (GABR) genes-GABRB3, GABRA5 and GABRG3. Deletion or duplication of 15q11-13 GABR genes occurs in multiple human neurodevelopmental disorders including Prader-Willi syndrome...

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Vydané v:	Human molecular genetics Ročník 16; číslo 6; s. 691
Hlavní autori:	Hogart, Amber, Nagarajan, Raman P, Patzel, Katherine A, Yasui, Dag H, Lasalle, Janine M
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	England 15.03.2007
Predmet:	Alleles Animals Cell Line, Tumor Cerebral Cortex - metabolism Child Child Development Disorders, Pervasive - genetics Chromosome Deletion Chromosomes, Human, Pair 15 CpG Islands DNA Methylation Epigenesis, Genetic Fathers Genomic Imprinting Humans Introns Methyl-CpG-Binding Protein 2 - metabolism Mice Polymerase Chain Reaction Prader-Willi Syndrome - genetics Receptors, GABA-A - genetics
ISSN:	0964-6906
On-line prístup:	Zistit podrobnosti o prístupe
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