Pancreatic Transdifferentiation Using β-Cell Transcription Factors for Type 1 Diabetes Treatment

Type 1 diabetes is a chronic illness in which the native beta (β)-cell population responsible for insulin release has been the subject of autoimmune destruction. This condition requires patients to frequently measure their blood glucose concentration and administer multiple daily exogenous insulin i...

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Bibliographic Details
Published in:	Cells (Basel, Switzerland) Vol. 11; no. 14; p. 2145
Main Authors:	Mahoney, Alexandra L. G., Nassif, Najah T., O’Brien, Bronwyn A., Simpson, Ann M.
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 08.07.2022 MDPI
Subjects:	Beta cells beta-cell transcription factors Blood glucose Blood levels Cell Transdifferentiation - genetics Cellular Reprogramming Techniques - methods Diabetes Diabetes mellitus (insulin dependent) Diabetes Mellitus, Type 1 - genetics Diabetes Mellitus, Type 1 - therapy Expression vectors Gene therapy Glucose Humans Hyperglycemia Insulin Insulin-Secreting Cells Pancreas pancreatic transdifferentiation Patients Physiology Population studies Review Transcription factors Transcription Factors - genetics type 1 diabetes viral vectors beta-cell transcription factors gene therapy type 1 diabetes pancreatic transdifferentiation viral vectors
ISSN:	2073-4409, 2073-4409
Online Access:	Get full text
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