Pancreatic Transdifferentiation Using β-Cell Transcription Factors for Type 1 Diabetes Treatment

Type 1 diabetes is a chronic illness in which the native beta (β)-cell population responsible for insulin release has been the subject of autoimmune destruction. This condition requires patients to frequently measure their blood glucose concentration and administer multiple daily exogenous insulin i...

Celý popis

Uložené v:
Podrobná bibliografia
Vydané v:Cells (Basel, Switzerland) Ročník 11; číslo 14; s. 2145
Hlavní autori: Mahoney, Alexandra L. G., Nassif, Najah T., O’Brien, Bronwyn A., Simpson, Ann M.
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Switzerland MDPI AG 08.07.2022
MDPI
Predmet:
Beta cells
beta-cell transcription factors
Blood glucose
Blood levels
Cell Transdifferentiation - genetics
Cellular Reprogramming Techniques - methods
Diabetes
Diabetes mellitus (insulin dependent)
Diabetes Mellitus, Type 1 - genetics
Diabetes Mellitus, Type 1 - therapy
Expression vectors
Gene therapy
Glucose
Humans
Hyperglycemia
Insulin
Insulin-Secreting Cells
Pancreas
pancreatic transdifferentiation
Patients
Physiology
Population studies
Review
Transcription factors
Transcription Factors - genetics
type 1 diabetes
viral vectors
beta-cell transcription factors
gene therapy
type 1 diabetes
pancreatic transdifferentiation
viral vectors
ISSN:2073-4409, 2073-4409
On-line prístup:Získať plný text
Tagy: Pridať tag
Žiadne tagy, Buďte prvý, kto otaguje tento záznam!
Popis
Shrnutí:Type 1 diabetes is a chronic illness in which the native beta (β)-cell population responsible for insulin release has been the subject of autoimmune destruction. This condition requires patients to frequently measure their blood glucose concentration and administer multiple daily exogenous insulin injections accordingly. Current treatments fail to effectively treat the disease without significant side effects, and this has led to the exploration of different approaches for its treatment. Gene therapy and the use of viral vectors has been explored extensively and has been successful in treating a range of diseases. The use of viral vectors to deliver β-cell transcription factors has been researched in the context of type 1 diabetes to induce the pancreatic transdifferentiation of cells to replace the β-cell population destroyed in patients. Studies have used various combinations of pancreatic and β-cell transcription factors in order to induce pancreatic transdifferentiation and have achieved varying levels of success. This review will outline why pancreatic transcription factors have been utilised and how their application can allow the development of insulin-producing cells from non β-cells and potentially act as a cure for type 1 diabetes.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ObjectType-Review-3
content type line 23
ISSN:2073-4409
2073-4409
DOI:10.3390/cells11142145