Rad51-mediated replication fork reversal is a global response to genotoxic treatments in human cells

Replication fork reversal protects forks from breakage after poisoning of Topoisomerase 1. We here investigated fork progression and chromosomal breakage in human cells in response to a panel of sublethal genotoxic treatments, using other topoisomerase poisons, DNA synthesis inhibitors, interstrand...

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Bibliographic Details

Published in:	The Journal of cell biology Vol. 208; no. 5; p. 563
Main Authors:	Zellweger, Ralph, Dalcher, Damian, Mutreja, Karun, Berti, Matteo, Schmid, Jonas A, Herrador, Raquel, Vindigni, Alessandro, Lopes, Massimo
Format:	Journal Article
Language:	English
Published:	United States 02.03.2015
Subjects:	Cell Line, Tumor DNA Damage DNA Replication HEK293 Cells Humans Poly(ADP-ribose) Polymerases - genetics Poly(ADP-ribose) Polymerases - metabolism Rad51 Recombinase - metabolism RecQ Helicases - genetics RecQ Helicases - metabolism Topoisomerase Inhibitors - toxicity
ISSN:	1540-8140, 1540-8140
Online Access:	Get more information
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