Micrometastases in breast cancer: long-term follow-up of the first patient cohort

"Micrometastases" can be identified in the bone marrow of patients with apparently localised breast cancer using an immunocytochemical stain for epithelial membrane antigen (EMA). Of 39 women who had marrow samples examined at the time of initial presentation (37), or with locally recurren...

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Veröffentlicht in:European journal of cancer (1990) Jg. 27; H. 3; S. 236
Hauptverfasser: Dearnaley, D P, Ormerod, M G, Sloane, J P
Format: Journal Article
Sprache:Englisch
Veröffentlicht: England 1991
Schlagworte:
Adult
Aged
Aged, 80 and over
Antigens, Neoplasm - analysis
Bone Marrow - pathology
Breast Neoplasms - immunology
Breast Neoplasms - pathology
Cohort Studies
Female
Humans
Lymph Nodes - pathology
Lymphatic Metastasis
Membrane Glycoproteins - analysis
Middle Aged
Mucin-1
Neoplasm Recurrence, Local
Prognosis
Time Factors
ISSN:0959-8049
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Zusammenfassung:"Micrometastases" can be identified in the bone marrow of patients with apparently localised breast cancer using an immunocytochemical stain for epithelial membrane antigen (EMA). Of 39 women who had marrow samples examined at the time of initial presentation (37), or with locally recurrent disease (2), 13 (33%) had samples which contained small numbers of EMA positive cells. 10 out of 23 (44%) lymph-node positive patients were marrow positive, compared to 1 out of 14 (7%) lymph node negative cases (P = 0.03). Long-term follow-up (median 9.5 years) has shown that 11 out of 13 (85%) patients with micrometastases have developed metastatic disease compared to 8 out of 26 (31%) with negative bone marrow aspirates (P less than 0.05). The small number of EMA positive cells detected in bone marrow samples probably reflects the high metastatic potential of primary or recurrent cancers rather than established microscopic deposits; it is not yet clear whether the finding of such micrometastases will act as an independent variable compared to established prognostic factors.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0959-8049
DOI:10.1016/0277-5379(91)90504-7