Highly potent human hematopoietic stem cells first emerge in the intraembryonic aorta-gonad-mesonephros region

Hematopoietic stem cells (HSCs) emerge during embryogenesis and maintain hematopoiesis in the adult organism. Little is known about the embryonic development of human HSCs. We demonstrate that human HSCs emerge first in the aorta-gonad-mesonephros (AGM) region, specifically in the dorsal aorta, and...

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Bibliographic Details
Published in:	The Journal of experimental medicine Vol. 208; no. 12; p. 2417
Main Authors:	Ivanovs, Andrejs, Rybtsov, Stanislav, Welch, Lindsey, Anderson, Richard A, Turner, Marc L, Medvinsky, Alexander
Format:	Journal Article
Language:	English
Published:	United States 21.11.2011
Subjects:	Animals Aorta - cytology Aorta - embryology Cell Proliferation Embryo, Mammalian - cytology Embryo, Mammalian - embryology Flow Cytometry Gonads - cytology Gonads - embryology Hematopoiesis - physiology Hematopoietic Stem Cells - cytology Humans Mesonephros - cytology Mesonephros - embryology Mice Mice, SCID Regenerative Medicine - methods
ISSN:	1540-9538, 1540-9538
Online Access:	Get more information
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