Auditory Sensory Memory and the Cholinergic System: Implications for Alzheimer's Disease

Auditory sensory memory represents one of the simplest types of short-term memory that can be studied electrophysiologically with mismatch negativity (MMN); a specific auditory event-related potential indexing automatic comparison of incoming stimuli to an existing memory trace. Previous results sug...

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Veröffentlicht in:NeuroImage (Orlando, Fla.) Jg. 14; H. 2; S. 376 - 382
Hauptverfasser: Pekkonen, Eero, Hirvonen, Jyrki, Jääskeläinen, Iiro P., Kaakkola, Seppo, Huttunen, Juha
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States Elsevier Inc 01.08.2001
Elsevier Limited
Schlagworte:
Adult
Aging
Alzheimer Disease - diagnosis
Alzheimer Disease - physiopathology
Alzheimer's disease
Anticholinergics
Attention - physiology
Auditory discrimination
Auditory evoked potentials
Cerebral Cortex - physiopathology
Cholinergic Fibers - physiology
Cholinergic transmission
Cognitive ability
Contingent Negative Variation - physiology
Cortex
Dominance, Cerebral - physiology
Double-Blind Method
Evoked Potentials, Auditory - physiology
Female
Glycopyrrolate
Glycopyrrolate - pharmacology
Humans
Information processing
Infusions, Intravenous
Intravenous administration
Latency
Magnetoencephalography
Male
Memory
Memory, Short-Term - physiology
Mismatch negativity
Neurodegenerative diseases
Pitch Perception - physiology
Reference Values
Scopolamine
Scopolamine Hydrobromide - pharmacology
Short term memory
Signal Processing, Computer-Assisted
ISSN:1053-8119, 1095-9572
Online-Zugang:Volltext
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Zusammenfassung:Auditory sensory memory represents one of the simplest types of short-term memory that can be studied electrophysiologically with mismatch negativity (MMN); a specific auditory event-related potential indexing automatic comparison of incoming stimuli to an existing memory trace. Previous results suggest that auditory sensory memory deteriorates in aging and especially in Alzheimer's disease (AD). It has remained unsettled, however, whether MMN is regulated by the cholinergic system, which is deteriorated in AD contributing to cognitive impairments. We recorded cortical auditory responses with a magnetometer from 13 healthy subjects after intravenous injection of scopolamine, centrally acting cholinergic antagonist, or glycopyrrolate, a drug with a peripheral anticholinergic properties without penetrating the blood–brain barrier, using a double-blind protocol. Scopolamine reduced MMNm amplitude in response to frequency, but not duration, change, increased P50m amplitude, and delayed N100m latency. These findings suggest that the cholinergic system regulates the frequency-specific comparison of incoming stimuli to existing memory trace and modulates the preattentive processing related to stimulus detection. Further, neural mechanisms responsible for cortical frequency- and duration-specific discrimination appear to have different sensitivities to cholinergic modulation. Auditory evoked potentials might be suitable to monitor cholinergic activity in AD.
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ISSN:1053-8119
1095-9572
DOI:10.1006/nimg.2001.0805