Prolonged measles virus shedding in human immunodeficiency virus-infected children, detected by reverse transcriptase-polymerase chain reaction

A reverse transcriptase-polymerase chain reaction assay was used to detect measles virus RNA in peripheral blood mononuclear cells, urine, and nasopharyngeal specimens from Zambian children during hospitalization and approximately 1-2 months after discharge. Of 47 children, 29 (61.7%) had prolonged...

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Veröffentlicht in:The Journal of infectious diseases Jg. 183; H. 4; S. 532
Hauptverfasser: Permar, S R, Moss, W J, Ryon, J J, Monze, M, Cutts, F, Quinn, T C, Griffin, D E
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States 15.02.2001
Schlagworte:
Adolescent
Antibodies, Viral - blood
Child
Child, Preschool
Female
HIV Infections - complications
HIV Seronegativity
HIV-1 - isolation & purification
Humans
Infant
Leukocytes, Mononuclear - virology
Male
Measles - complications
Measles - virology
Measles virus - genetics
Measles virus - immunology
Measles virus - isolation & purification
Measles virus - physiology
Nasopharynx - virology
Reverse Transcriptase Polymerase Chain Reaction
RNA, Viral - analysis
Time Factors
Urine - virology
Virus Shedding - physiology
Zambia
Zambia
ISSN:0022-1899
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Zusammenfassung:A reverse transcriptase-polymerase chain reaction assay was used to detect measles virus RNA in peripheral blood mononuclear cells, urine, and nasopharyngeal specimens from Zambian children during hospitalization and approximately 1-2 months after discharge. Of 47 children, 29 (61.7%) had prolonged measles virus shedding, as defined by detection of measles virus RNA in > or =1 specimen obtained 30-61 days after rash onset. Ten (90.9%) of 11 human immunodeficiency virus (HIV)-infected children had prolonged measles virus shedding, compared with 19 (52.8%) of 36 HIV-uninfected children (P=.02). Prolonged measles virus shedding did not correlate with levels of measles virus-specific antibody. HIV-infected children with measles may have a prolonged infectious period that potentially enhances measles virus transmission and hinders measles control.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0022-1899
DOI:10.1086/318533