Reshaping the Tumor Stroma for Treatment of Pancreatic Cancer

Pancreatic cancer is accompanied with a fibrotic reaction that alters interactions between tumor cells and the stroma to promote tumor progression. Consequently, strategies to target the tumor stroma might be used to treat patients with pancreatic cancer. We review recently developed approaches for...

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Bibliographic Details
Published in:Gastroenterology (New York, N.Y. 1943) Vol. 154; no. 4; p. 820
Main Authors: Vennin, Claire, Murphy, Kendelle J, Morton, Jennifer P, Cox, Thomas R, Pajic, Marina, Timpson, Paul
Format: Journal Article
Language:English
Published: United States 01.03.2018
Subjects:
pancreatic cancer
invasion
metastasis
patient-derived models
stromal remodeling
diagnostic tool
ISSN:1528-0012, 1528-0012
Online Access:Get more information
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Summary:Pancreatic cancer is accompanied with a fibrotic reaction that alters interactions between tumor cells and the stroma to promote tumor progression. Consequently, strategies to target the tumor stroma might be used to treat patients with pancreatic cancer. We review recently developed approaches for re-shaping the pancreatic tumor stroma and discuss how these might improve patient outcomes. We also describe relationships between the pancreatic tumor extracellular matrix, the vasculature, the immune system, and metabolism and discuss the implications for the development of stromal compartment-specific therapies.
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ISSN:1528-0012
1528-0012
DOI:10.1053/j.gastro.2017.11.280