Keeping Mammalian Mutation Load in Check: Regulation of the Activity of Error-Prone DNA Polymerases by p53 and p21

To overcome DNA lesions that block replication the cell employs translesion DNA synthesis (TLS) polymerases, a group of low fidelity DNA polymerases that have the capacity to bypass a wide range of DNA lesions. This TLS process is also termed error-prone repair, due to its inherent mutagenic nature....

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