Stimulation of lymphangiogenesis via VEGFR-3 inhibits chronic skin inflammation

The role of lymphangiogenesis in inflammation has remained unclear. To investigate the role of lymphatic versus blood vasculature in chronic skin inflammation, we inhibited vascular endothelial growth factor (VEGF) receptor (VEGFR) signaling by function-blocking antibodies in the established keratin...

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Vydáno v:	The Journal of experimental medicine Ročník 207; číslo 10; s. 2255
Hlavní autoři:	Huggenberger, Reto, Ullmann, Stefan, Proulx, Steven T, Pytowski, Bronislaw, Alitalo, Kari, Detmar, Michael
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 27.09.2010
Témata:	Animals Antibodies, Blocking - immunology CD8-Positive T-Lymphocytes - immunology Chronic Disease Dermatitis - genetics Dermatitis - immunology Dermatitis - metabolism Dermatitis - therapy Keratin-14 - genetics Lymphangiogenesis Mice Mice, Transgenic Skin - blood supply Skin - immunology Skin - metabolism Vascular Endothelial Growth Factor A - genetics Vascular Endothelial Growth Factor D - administration & dosage Vascular Endothelial Growth Factor D - immunology Vascular Endothelial Growth Factor Receptor-2 - antagonists & inhibitors Vascular Endothelial Growth Factor Receptor-2 - immunology Vascular Endothelial Growth Factor Receptor-3 - antagonists & inhibitors Vascular Endothelial Growth Factor Receptor-3 - immunology Vascular Endothelial Growth Factor Receptor-3 - metabolism
ISSN:	1540-9538, 1540-9538
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