Circulating microRNAs as potential markers of human drug‐induced liver injury

New biomarkers of liver injury are required in the clinic and in preclinical pharmaceutical evaluation. Previous studies demonstrate that two liver‐enriched microRNAs (miR‐122 and miR‐192) are promising biomarkers of acetaminophen‐induced acute liver injury (APAP‐ALI) in mice. We have examined these...

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Bibliographic Details
Published in:	Hepatology (Baltimore, Md.) Vol. 54; no. 5; pp. 1767 - 1776
Main Authors:	Starkey Lewis, Philip J., Dear, James, Platt, Vivien, Simpson, Kenneth J., Craig, Darren G.N., Antoine, Daniel J., French, Neil S., Dhaun, Neeraj, Webb, David J., Costello, Eithne M., Neoptolemos, John P., Moggs, Jonathan, Goldring, Chris E., Park, B. Kevin
Format:	Journal Article
Language:	English
Published:	Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.11.2011 Wiley Wolters Kluwer Health, Inc
Subjects:	Acetaminophen - poisoning Acute Disease Adolescent Adult Aged Alanine Transaminase - blood Analgesics, Non-Narcotic - poisoning Biological and medical sciences Biomarkers Biomarkers - blood Chemical and Drug Induced Liver Injury - blood Chemical and Drug Induced Liver Injury - diagnosis Chemical and Drug Induced Liver Injury - surgery Diagnostic Techniques, Digestive System Drug toxicity and drugs side effects treatment Female Gastroenterology. Liver. Pancreas. Abdomen Hepatology Humans Liver Liver Transplantation Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences MicroRNAs MicroRNAs - blood Middle Aged Pharmacology. Drug treatments Prospective Studies Toxicity: digestive system Young Adult Human Digestive diseases Hepatic disease Hepatotoxicity Gastroenterology
ISSN:	0270-9139, 1527-3350, 1527-3350
Online Access:	Get full text
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